新农药叶枯灵的体外代谢转化研究  

Study on Metabolism and Biotrans-formation of a New Fungicide Ye-Kuling in Vitro

作　　者：高宁[1] 孙棉龄[2] 王宇[2] 

机构地区：[1]第三军医大学,重庆630038 [2]华西医科大学

出　　处：《中国公共卫生学报》1992年第6期347-350,共4页

摘　　要：本文采用 HPLC、TLC、UV、IR 和 MS 对叶枯灵经体外代谢后所形成的代谢产物进行分离和鉴定。结果表明,叶枯灵经体外代谢后所形成的3种代谢产物分别为肼叉-1,3-二噻茂烷,2-苯甲酰肼叉-1,3-二噻茂烷-S-氧和苯甲酸。叶枯灵经酰胺酶的催化可进行水解作用。叶枯灵还可经肝微粒体混合功能氧化酶的作用进行 S-氧化反应。The metabolism and biotransformation of a new fungicide Yekuling was studied in vitro. Three metabolites were isolated and purified by means of HPLC and TLC.They were iden- tified to be 1,3-dithiolan-2-ylidenehydrazine,be- nzoic acid,1.3-dithiolan-s-oxo-2-ylidenehydra- zide and benzoic acid.Yekuling was sulfoxida- ted by rat liver microsomal MFO in the pre- sence of NADPH to produce sulfoxide.Yekuling was also hydrolyzed by amidase to form ben- zoic acid and 1,3-dithiolan-2-ylidenehydrazine,

关 键 词：代谢转化 敌枯唑 

分 类 号：R114[医药卫生—卫生毒理学]