胃癌组织VEGF,Flt1,bFGF,P^(53)表达与胃癌预后的关系  

Relationship between expression of VEGF, Flt1, bFGF and P^(53)and outcome in patients with gastric carcinoma

作　　者：段伦喜[1] 钟德午[1] 胡辅珍[1] 赵华[1] 杨竹林[1] 易文君[1] 舒国顺[1] 华颂文[1] 

机构地区：[1]中南大学湘雅二医院普外科,湖南省长沙市410011

出　　处：《世界华人消化杂志》2004年第3期546-549,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨胃癌中VEGF,Fltl,bFGF,P53的表达及意义方法:应用SABC免疫组化法,研究VEGF,Fltl,bFGF, P53在胃癌中表达及与胃癌生长转移、临床病理特征、预后的关系. 结果:胃癌VEGF表达与肿瘤浸润深度有关(浆膜、浆膜外vs 肌层和黏膜层,P<0.01).P53表达与淋巴结转移相关(P53 阳性淋巴结转移组vs P53阴性淋巴结无转移组,P<0.05). VEGF与Fltl表达呈正相关(VEGF表达在Fltl阳性组vs在Fltl阴性组,P<0.01);影响胃癌预后的因素有临床病理分期、VEGF表达、肿瘤浸润深度、手术方式.Kaplan-Meier 研究显示VEGF表达与胃癌生存预后相关(P<0.05).Fltl, bFGF,P53表达与生存预后无关(P>0.05). 结论:P53表达与淋巴结转移相关.VEGF表达与肿瘤浸润深度和胃癌生存预后相关,VEGF表达可作为预测胃癌预后一项很好的指标.AIM: To investigate the relationship between the expression of VEGF, Flt1, bFGF and P53, the dinicopathological characteristics and outcome in patients with gastric carcinoma. METHODS: The relationship between VEGF, Fltl, bFGF, P53 expression and dinicopathological characteristics and outcome in the patient was assessed by streptoavidin-biotin method of immunohistochemistry with polyclonal antibodies against VEGF, Flt1, bFGF, and P53 protein. The survival curves were formulated using Kaplan-Meier method and analyzed by the log-rank test, and the influence of each variable on suvival was assessed by the Cox' s proportional hazard model. RESULTS: VEGF expression was closely correlated with serosal invasion (Se, Sei invasion vs Pm, SS and M, SM invasion, P <0.01). Expression of P53 was obviously higher in the patients with lymph node metastasis than those without (lymph node metastasis vs non-lymph node metastasis, P <0.05). There was a positive correlation between VEGF and Fltl expression (VEGF expression in Fltl positive group vs Fltl negative group, P <0.01). The factors that affected the prognosis in patients with gastric carcinoma were PTNM stage, VEGF expression, serosal invasion, and surgical curability. Fltl, bFGF, and P53 expression had no influence on the prognosis of patients with gastric carcinoma (P>0.05). CONCLUSION: P53 expression has significant relationship with lymph node metastasis in gastric carcinoma. VEGF expression is correlated with serosal invasion and the prognosis and may be a good prognostic indicator in gastric carcinoma.

关 键 词：胃癌 VEGF Flt1 BFGF p53 预后 肿瘤浸润 肿瘤转移 血管生成 

分 类 号：R735.2[医药卫生—肿瘤]