大鼠胃电节律失常模型胃肌间Cajal间质细胞含量的变化  

Changes of interstitial cell of Cajal content in a rat model of electrogastric dysrhythmias

作　　者：李宇航[1] 王庆国[1] 陈萌[1] 杨美娟[1] 赵丽云[1] 李丽娜[1] 张冬梅[1] 王丹[1] 

机构地区：[1]北京中医药大学基础医学院,北京市100029

出　　处：《世界华人消化杂志》2004年第3期639-641,共3页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30271575教育部优秀青年教师资助计划项目;No.200240~~

摘　　要：目的:观察胃电节律失常大鼠模型中胃肌间Cajal间质细胞(Interstitial Cells of Cajal,ICC)含量的变化,以探讨该模型病理机制,为今后的研究奠定基础. 方法:采用不规则喂养法制备大鼠胃电节律失常模型,用免疫组化法检测其胃肌间c-kit阳性I CC含量的变化. 结果:胃电节律失常模型大鼠的胃肌间c-kit阳性ICC含量比正常对照组明显升高(P<0.001). 结论:张氏大鼠胃电节律失常模型中作为起搏细胞的ICC的增加,可能导致异常的胃电起搏点的增加,从而引发胃电节律失常.AIM: To observe the change of the interstitial cells of Cajal (ICC) content in the stomach wall in rats with electrogastric dysrhythmias, and to discuss the pathological mechanism of the rat model. METHODS: Irregular feeding was adopted to establish a rat model of electrogastric dysrhythmias. Immunohis-tochemical staining was used to detect the content of c-kit positive ICC. RESULTS: The content of ICC in the model group was higher than that in the control group, and showed a significant difference from that in the control group CONCLUSION: The increase of the ICC content in the model group may lead to the increase of the abnormal pacing impulse points, which results in the electrogastric dysrhythmias in the stomach. Li YH, Wang QG, Chen M, Yang MJ, Zhao LY, Li LN, Zhang DM, Wang D. Changes of interstitial cell of Cajal content in a rat model of electrogastric dysrhythmias. Shijie Huaren Xiaohua Zazhi 2004;12(3):639-641

关 键 词：大鼠 胃电节律失常 胃肌间Cajal间质细胞 免疫组化法 动物模型 胃功能性疾病 

分 类 号：R573[医药卫生—消化系统]