胰腺癌扩大切除术后经动脉化疗泵区域灌注化疗30例  

Regional perfusion chemotherapy via arterial chemotherapy pump after extended resection for pancreatic cancer

作　　者：吕平[1] 刘芳[2] 王春友[1] 熊炯炘[1] 陈立波[1] 万赤丹[1] 高金波[1] 润晓勤[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胰腺外科中心,湖北省武汉市430022 [2]华中科技大学同济医学院附属协和医院放射科CT室,湖北省武汉市430022

出　　处：《世界华人消化杂志》2004年第3期734-737,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨进—步提高胰腺癌扩大切除术患者生存率的方法方法:回顾性分析胰腺癌扩大切除术后患者中未行辅助治疗(对照组,n=27)或经动脉化疗泵行5-氟尿嘧啶(5-FU)区域灌注(5-FU组,n=30)两组患者的临床资料并比较其预后. 结果:5-FU组(中位生存期16 mo)生存率显著高于对照组(中位生存期12 mo)(P<0.05,Kaplan-Meier生存分析,Log rank检验);5-FU组2 a及3 a累积生存率分别为37%和26%, 均显著高于对照组(分别为15%和5%)(P<0.05,X2检验); 5-FU组肝转移累积死亡率明显低于对照组(P<0.05,Log rank检验);5-FU组WHO化疗毒副反应分级多为WHO I, Ⅱ级,未出现WHO Ⅳ级毒副反应. 结论:胰腺癌扩大切除术后经动脉化疗泵行5-FU区域灌注化疗能明显减少肝脏转移且毒副反应较轻,可进一步提高患者生存率.AIM: To improve the survival rate of pancreatic cancer patients after extended pancreatectomy. METHODS: The clinical data of pancreatic cancer patients were reviewed after extended pancreatectomy, without adjuvant therapy (control group, n =27) or with 5-fluorou-racil (5-FU) regional perfusion via arterial chemotherapy pump (5-FU group, n =30), and the prognosis of the two groups were compared. RESULTS: The survival rate in 5-FU group (median survival time=16 months) was significantly better than that in control group (median survival time=12 months) (P<0.05, Kaplan-Meier survival analysis, Log rank test); The 2-, 3-year cumulative survival rates in 5-FU group were 37% and 26% respectively, significantly better than those in the control group (15% and 5% respectively) (P<0.05, X2 test); The cumulative rate of death by hepatic metastasis alone in 5-FU group was significantly lower than that in control group (P<0.05,Log rank test); The WHO grade toxicities of 5-FU group generally were WHO I and II, and no WHO IV toxic events were observed. CONCLUSION: 5-FU regional perfusion chemotherapy via arterial chemotherapy pump after extended resection for pancreatic cancer can reduce the hepatic metastasis with relatively mild toxicities and increase the survival rate of the patients.

关 键 词：胰腺癌 扩大切除术 化疗泵 区域灌注化疗 毒副反应 预后 

分 类 号：R735.9[医药卫生—肿瘤]