吗啡依赖大鼠长期戒断后的觅药行为与伏膈核Fos表达  

MORPHINE PREFERENCE FOLLOWING PROLONGED ABSTINENCE ASSOCIATION WITH FOS EXPRESSION IN THE NUCLEUS ACCUMBENS

作　　者：梁秦川[1] 高国栋[1] 熊华[2] 李维新[1] 

机构地区：[1]第四军医大学唐都医院神经外科,西安710038 [2]第四军医大学流行病学教研室,西安710038

出　　处：《中国药物依赖性杂志》2004年第1期33-36,共4页Chinese Journal of Drug Dependence

基　　金：军队临床高新技术重大项目 ( 2 0 0 2 18)

摘　　要：目的 :研究吗啡依赖大鼠长期停药后的觅药行为和伏膈核各亚区 (外壳区、核心区 )的Fos蛋白表达。方法 :大鼠皮下注射吗啡使其成瘾 ,停药 2月后进行条件性位置偏爱试验 ,并检测伏膈核核心区和外壳区的Fos蛋白表达。结果 :吗啡预处理组大鼠的位置偏爱效应明显强于盐水预处理组 ,在伏膈核核心区的Fos蛋白表达显著高于对照组。结论 :位置偏爱行为与吗啡相关环境刺激引起伏膈核核心区的激活有关 。Objective :To observe the drug-seeking behaviour in abstinent rats which were chronically morphine-pretreated and determine NAc core and shell involved in this behavior. Methods : Preferences for morphine-associated environments and Fos expression in NAc core and shell were measured 35 days after withdrawal of chronic morphine treatment. Results : The preference for the morphine environment was greatly increased by morphine pretreatment. The morphine pretreated group showed significant higher Fos levels than the control groups in the NAc core. Conclusion : There is a relationship between conditioned place preference behavior and neural indices of activation in the NAc core in response to morphine-conditioned cues, which may be chronically modulated by prior morphine exposure.

关 键 词：吗啡依赖 大鼠 戒断症状 觅药行为 伏膈核 FOS蛋白 药物成瘾 慢性脑疾病 

分 类 号：R749.61[医药卫生—神经病学与精神病学]