静力训练结合推拿手法治疗对老年大鼠蛋白质代谢的影响  

Effects of Isometric Exercise and Chinese Massage on Protein Metabolism in Senior Rats

作　　者：张宏[1] 严隽陶[1] 徐俊[2] 吴信忠[2] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院推拿科,上海200437 [2]上海中医药大学针灸推拿学院,上海201203

出　　处：《上海中医药大学学报》2004年第1期35-37,共3页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市卫生局中医药科研基金资助项目(00-P-08;02-QN-002)

摘　　要：为探索骨骼肌蛋白质代谢增龄性变化特征及静力训练结合推拿手法治疗的效果与机理。SD大鼠分为6月龄对照组、18月龄对照组及18月龄治疗组。治疗组采用倒置悬吊法训练,并结合推拿手法治疗,共6周。测定治疗前后骨骼肌蛋白质、尿肌酐(CRE)和尿3-甲基组氨酸(3-MH)的含量。结果:老年大鼠骨骼肌蛋白含量降低,24h尿CRE及3-MH排出量增高;治疗后老年大鼠骨骼肌蛋白质含量升高,CRE及3-MH排出量降低。结论:大鼠骨骼肌蛋白随着年龄而合成减少、分解加快;静力训练结合推拿手法治疗,可以逆转这种增龄性改变。To study the characteristics of skeletal muscles with aging in protein metabolism and the mechanisms of prevention by isometric exercise and Chinese massage,48 rats were divided into the control group aged 6 months,the control group aged 18 months,and the therapeutic group aged 18 months. The last group was treated by isometric exercise and Chinese massage manipulation for 6 weeks. Protein in skeletal muscles and creatinine and 3-Methylhistidine in urine were measured in experiment rats. Results: The results indicated that protein in skeletal muscles obviously descended, and creatinine and 3-Methylhistidine in urine in 24 hours obviously increased in the senior rats. The treatment of isometric exercise along with Chinese massage manipulation could enhance protein in skeletal muscles,and depress creatinine and 3-Methylhistidine in urine. Conclusion:Protein anabolism was gradually decreasing and protein catabolism was gradually increasing in rats with aging. Chinese traditional rehabilitation maneuvers, isometric exercise of Chinese massage along with Chinese massage manipulation, could correct the abnormal protein metabolism and delay the skeletal muscles degeneration with aging.

关 键 词：静力训练 推拿手法 治疗 老年人 大鼠 蛋白质代谢 骨骼肌减少症 尿肌酐 CRE 

分 类 号：R244.1[医药卫生—针灸推拿学] R-332[医药卫生—中医临床基础]