万拉法新治疗老年期抑郁症的疗效观察  

The curative effects of venlafaxine and fluoxetine in patients with senile depression

作　　者：韩嫣[1] 万予新[1] 马振武[1] 

机构地区：[1]河南省精神病医院,河南新乡453002

出　　处：《临床心身疾病杂志》2004年第1期9-10,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的 比较万拉法新与氟西汀治疗老年期抑郁症的疗效及副反应。方法 将62例老年期抑郁症患者随机分为两组,其中万拉法新组32例,予万拉法新150mg·d-1·Bid·PO。氟西汀组30例,予氟西汀40mg·d-1·qd·PO。两组进行为期6w的治疗,并于疗前及疗后1、2、4、6w末采用汉密尔顿抑郁量表(HAMD)及副反应量表(TESS)进行评定。结果 万拉法新组显效率84.4％,氟西汀组显效率83.3％,经卡方检验,两组无显著性差异(P>0.05)。万拉法新较氟西汀起效快(P<0.05)。副反应均较轻微,两组元显著性差异。结论 万拉法新起效快,副反应小,治疗老年期抑郁症疗效好。Objective To compare the efficacies and side effects of venlafaxine and fluoxetine in patients with senile depression. Methods Sixty-two patients with senile depression were randomly divided into 2 groups: venlafaxine group(n=32, 150mg/d,b. i. d. ) and fluoxetine group(n=30, 40mg/d,q. d. ) for 6 weeks. Both groups were assessed by HAMD and TESS before treatment and at the end of 1st, 2nd, 4th, 6th week of treatment. Results The effectual rates of the 2 groups were 84. 4%(venlafaxine group) and 83. 3% (fluoxetine group) , which showed no significant difference (X2 test, P>0. 05). Venlafaxine took effect faster than fluoxetine did(P<0. 01). Conclusion Venlafaxine takes effect faster and has better curative effect and milder side effects in patients with senile depression.

关 键 词：万拉法新 氟西汀 老年期抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]