精神分裂症患者的干扰素及白介素表达水平的研究  

A study of expression level of interferon and interlenukin in schizophrenics

作　　者：汪辉[1] 杨小华[2] 宋志艳[1] 钱惠忠[1] 陈梅芳[1] 陈致宇[1] 杨金芳[1] 郑海雅[2] 

机构地区：[1]杭州市第七人民医院,310013 [2]浙江大学免疫学研究所

出　　处：《上海精神医学》2004年第1期15-16,19,共3页Shanghai Archives of Psychiatry

摘　　要：目的　分析精神分裂症患者外周血单个核细胞 (PBMCs)IFN γ、IL 12、IL 18的表达水平 ,从细胞因子水平探讨精神分裂症患者的免疫功能状况。方法　用酶联免疫法 (ELISA)检测 34例精神分裂症患者和 2 0例正常人PBMCsIFN γ、IL 12、IL 18的表达水平。结果　精神分裂症患者PBMCs的IFN γ、IL 12、IL 18的表达水平比正常人显著增高。结论　PBMCs的IFN γ、IL 12、IL 18的表达增强 ,提示精神分裂症患者免疫功能混乱。Objective: To study the expression level of IFN-γ、IL-12 and IL-18 in peripheral blood mononuclear cells (PBMCs) in schizophrenics and to investigate the immune function of schizophrenic patients upon cytokine levels. Methods: The expression level of IFN-γ、IL-12 and IL-18 in PBMCs was detected with ELISA in 34 schizophrenic patients and 20 controls. Results: The Expression of IFN-γ、IL-12 and IL-18 in PBMCs in patients with schizophrenia were greatly enhanced compared with that of normal controls. Conclusion: The enhanced expression of IFN-γ、IL-12 and IL-18 in PBMCs indicated that the immune function of patients with schizophrenia may be disordered.

关 键 词：精神分裂症 干扰素 白细胞介素 外周血 单个核细胞 酶联免疫法 检测 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]