细胞因子水平与肝纤维化患者治疗和预后的相关研究  

Study on the relationship between the cytokines level and the treatment and prognosis in patients with liver fibrosis

作　　者：朱金水[1] 余小虎[1] 俞华芳[1] 沈波[1] 朱励[1] 李沁[1] 孙群[1] 

机构地区：[1]上海交通大学附属第六人民医院消化科,上海200233

出　　处：《检验医学》2004年第2期101-103,共3页Laboratory Medicine

基　　金：上海市重大医学课题基金资助项目 (99ZDI0 0 1)

摘　　要：目的　探讨肝纤维化患者血清细胞因子白细胞介素 6 (IL 6 )、白细胞介素 (IL 8)、白细胞介素 10 (IL 10 )水平与疾病预后之间的关系。方法　采用酶联免疫吸附试验 (ELISA)法测定肝纤维化患者治疗前后的细胞因子水平。结果　 6 0例肝功能减退的肝纤维化患者外周血清IL 6、IL 8水平较正常对照组显著升高 ,IL 10水平则较正常对照组显著降低。采用口服氧化苦参碱治疗 3个月后肝功能减退组IL 6、IL 8水平较治疗前降低 ,IL 10水平升高 ,但差异无显著性 ;3个月后肝功能恢复组的IL 6、IL 8水平较治疗前显著降低 ,IL 10水平则显著升高。结论　细胞因子水平与肝纤维化患者预后有关 ,其血清水平可作为判断肝纤维化患者预后的指标之一 。Objective To study the relationship among between levels of cytokines and the treatment and prognosis of patients with liver fibrosis. Methods Serum levels of cytokines were measured by ELISA in patients with liver fibrosis and control group. Results The serum levels of IL 6, IL 8 in patients with liver fibrosis were significantly higher than control group. IL 10 was obviously lower than control group. IL 6 and IL 8 were lower after oral oxymatrine therapy for three months than that before therapy in aggravated hepatic function group. IL 10 was higher than that before therapy. But there was no obvious difference between them. Serum levels of IL 6, IL 8 were significantly decreased in restored hepatic function group while IL 10 was significantly increased after therapy. Conclusions IL 6, IL 8 and IL 10 may be correlated with the treatment and prognosis of patients with liver fibrosis. They may be one of markers to judge the prognosis of patients with liver fibrosis, oxymatrine may have an important inhibition role on liver fibrosis.

关 键 词：细胞因子 肝纤维化 预后 酶联免疫吸附试验 白细胞介素 氧化苦参碱 

分 类 号：R575.2[医药卫生—消化系统]