β-环糊精交联聚合物对胆红素吸附性能的研究  

Cross-Linked β-Cyclodextrin Polymer Used for Bilirubin Removal

作　　者：郑朝俊[1] 黄晓冬[1] 孔亮[1] 厉欣[1] 邹汉法[1] 

机构地区：[1]中国科学院大连化学物理研究所国家色谱研究分析中心,辽宁大连116011

出　　处：《色谱》2004年第2期128-130,共3页Chinese Journal of Chromatography

摘　　要：考察了β 环糊精交联聚合物对胆红素的动力学吸附曲线,以及温度、pH值、胆红素初始浓度和牛血清白蛋白对去除率的影响。实验结果表明这种聚合物材料对胆红素具有较快的吸附速度,并且在较高的温度下有利于胆红素的吸附。当溶解胆红素的磷酸盐缓冲液的pH为7 8,胆红素起始质量浓度为40mg/L时,β 环糊精聚合物对胆红素的去除率高达92 6%。随着胆红素初始质量浓度的增加,胆红素的去除率下降,但吸附量增加。A new material for adsorption of bilirubin was synthesized with cross-linking reaction of β-cyclodextrin. The kinetic adsorption behaviors of bilirubin such as the effects of temperature, pH, the initial bilirubin concentration as well as bovine seum albumin on the removal of bilirubin have been investigated. It is demonstrated that bilirubin could be adsorbed well on the prepared sorbent quickly and higher temperature favored the adsorpion of bilirubin. The percentage of removal of bilirubin reached 92.6% with initial bilirubin concentration of 40 (mg/L) in phosphate buffer at pH 7.8. With the increase of initial bilirubin concentration, the percentage of removal of bilirubin decreased; however, the adsorption capacity increased.

关 键 词：胆红素 吸附性能 Β-环糊精交联聚合物 吸附动力学 高未结合胆红素血症 新生儿疾病 去除方法 治疗 

分 类 号：R722.1[医药卫生—儿科]