新化合物PPVP在大鼠动脉粥样硬化模型上抗动脉粥样硬化分子机制的研究  

Molecular mechanisms for the novel compound PPVP against atherosclerosis in rat fed with hypercholesterol diet

作　　者：山丽梅[1] 赵艳玲[1] 张锦超[2] 崔文玉[3] 汪海[3] 

机构地区：[1]解放军第302医院药学部,北京100039 [2]军事医学科学院生物工程研究所,北京100071 [3]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2004年第3期255-258,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划项目NoG 1 9980 51 1 1 2

摘　　要：目的　研究新化合物PPVP抗动脉粥样硬化作用的分子机制。方法　在高血脂诱发大鼠早期动脉粥样硬化模型上 ,观察PPVP给药组动物血液及血管组织中重要的动脉粥样硬化相关因子表达的情况。结果　PPVP对血脂 ,ET 1和PGI2 水平无明显影响 ,但明显增加血清中NO含量 ,降低血清TXA2 含量 ,抑制趋化因子IL 8的过度表达。AIMTo investigate the anti-atherosclerosis mechanisms of the novel compound PPVP. METHODSThirty-six male rats were a ssigned to control, model and PPVP 5 mg·kg -1 groups randomly. The rats in model and PPVP 5 mg·kg -1 groups were fed with hypercholesterol diet for inducing atherolcerosis model. The following variables were measured: HE stainin g of rat aorta; serum level of TC, LDL-CHO, HDL-CHO, IL-8, ET-1, PGI 2, TXA 2 and NO. RESULTSPPVP increased serum level of NO, decreased plasma level of TXA 2 and inhibited the over expression of IL-8. CONC LUSIONThe anti-atherogenic effect of PPVP seems to be closely involved in increasing serum NO level, decreasing plasma level of TXA 2, and inhibiting over expression of IL-8. The result also suggests that the anti-atherogenic ef fect of PPVP in high cholesterol-fed rat may not due to the regulation of plasm a lipid profile, plasma level of ET-1 and PGI 2.

关 键 词：动脉粥样硬化 PPVP 一氧化氮 IL-8 

分 类 号：R-332[医药卫生] R284.1