动脉粥样硬化性血栓性脑梗死病人血清对氧磷酶-1活性变化及临床意义  

Determination and Clinical Significance of Serum Paraoxonase Activity in Patients with Cerebral Atherosclerotic Infarction

作　　者：贺勇[1] 尤志珺[1] 周少华[1] 邓晓玲[1] 黄明玮[1] 

机构地区：[1]湖北省十堰市郧阳医学院附属人民医院

出　　处：《中西医结合心脑血管病杂志》2004年第4期212-214,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的　探讨动脉粥样硬化性血栓性脑梗死 (ATCI)病人血清对氧磷酶 -1(PON -1)水平变化及其临床意义。方法　应用酶联免疫分析法测定 60例ATCI病人急性期和恢复期血清PON -1活性及血浆ox -LDL的浓度 ,比较轻、中、重 3型病人的PON -1活性的变化。结果　ATCI病人急性期PON -1活性显著低于健康对照者。重型AT CI病人PON -1活性显著低于轻型病人。病人血浆ox -LDL的浓度较对照组明显升高。结论　PON-1活性的降低在ATCI的发病中起一定的作用。Objective To investigate the changes of the serum paraoxonase activity in patients with atherosclerosis cerebral infarction and its clinical significance.Methods The serum PON-1 activity and ox-LDL levels were determined by ELISA from 60 patients with ATCI and 20 normal controls.Results The activity of PON-1 significantly decreased in ATCI group than in controls ,while the levels of ox-LDL were higher in patients group.Conclusion The decrease of serum PON-1 activity promoted atherosclerosis which could lead to cerebral infarction.

关 键 词：动脉粥样硬化 血栓性脑梗死 血清 氧磷酶-1 活性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]