异博定对视网膜缺血再灌注损伤ERG的影响  

Effects of verapamil in retina ERG after ischemia-reperfusion injury

作　　者：李国栋[1] 姜德咏[1] 游志鹏[1] 赵宏伟[1] 唐朝珍[1] 

机构地区：[1]中南大学湘雅二医院眼科,长沙市410011

出　　处：《实用医学杂志》2004年第4期360-361,共2页The Journal of Practical Medicine

摘　　要：目的 :建立视网膜缺血再灌注损伤模型 ,用视网膜电 (流 )图 (ERG)观察异博定对视网膜ERG的影响。方法 :通过结扎大鼠左颈总动脉 1h ,然后再灌注 ,同时向腹腔注射异博定 ,检测 1h ,6h ,12h ,2 4h ,48h ,72h视网膜ERG的变化。结果 :再灌注 6h后 ,异博定组视网膜的ERG与对照组相比 ,有明显的提高。结论 :异博定可以促进缺血再灌注损伤视网膜ERGb波的恢复。Objective To establish the model of retina ischemia-reperfusion injury, observe the effect of verapamil on retina ERG. Methods Ligate rat left common carotid artery 1 h, then reperfuse, inject verapamil intraperitoneally at the same time, exam retina ERG in 1 h, 6 h, 12 h, 24 h, 48 h, 72 h. Results 6 h after reperfusion, retina ERG recover better in verapamil group than in contrast group. Conclusion It is significance of verapamil to promote retina ERG recovery from ischemia-reperfusion injury.

关 键 词：视网膜电图 异博定 视网膜缺血 再灌注损伤 大鼠 眼压 

分 类 号：R774.1[医药卫生—眼科]