Fcγ受体IIA基因多态性与慢性牙周炎易感性的相关性研究  

The Association between Fcγ Receptor ⅡA Gene Polymorphism and Susceptibility to Chronic Periodontitis in Chinese Han Nationality

作　　者：唐燕[1] 章锦才[2] 张蕴惠[1] 庞若愚[2] 

机构地区：[1]四川大学华西口腔医院牙周病科,四川成都610041 [2]广东省口腔医院牙周病科,广东广州510280

出　　处：《华西口腔医学杂志》2004年第2期158-161,共4页West China Journal of Stomatology

基　　金：国家自然科学基金资助项目 (39970 793)

摘　　要：目的　探讨Fcγ受体ⅡA基因多态性和慢性牙周炎的易感性相关关系。方法　采用序列特异性引物多聚酶链反应 (PCR_SSP) ,对 6 3例重度慢性牙周炎患者、10 3例轻中度慢性牙周炎患者及 80名健康对照者的Fcγ受体ⅡA基因多态性进行检测 ,比较各组间基因型分布及等位基因频率的差异。结果　FcγRⅡA_R R131基因型在重度慢性牙周炎与健康对照组之间的分布差异有显著性 (P <0 0 12 5 ) ,而在轻中度慢性牙周炎组与健康对照组、重度慢性牙周炎组与轻中度慢性牙周炎组之间的分布差异无显著性 (P >0 0 12 5 )。结论　FcγRⅡA_R R131基因型与慢性牙周炎的严重程度相关 ,提示其可能与汉族人群慢性牙周炎的易感性有关。Objective To investigate the association between Fcγ receptor ⅡA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality.Methods DNA samples were collected with buccal swabs from 63 patients with severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fcγ receptor ⅡA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.Results It was found that the frequency of FcγRIIA-R/R131 genotype was significantly higher in patients with severe CP (19.05%) compared to that of the healthy controls (P<0.012 5).Conclusion The Fcγ RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.

关 键 词：Fcγ受体ⅡA基因 基因多态性 慢性牙周炎 CP 牙周炎 细胞免疫 

分 类 号：R781.4[医药卫生—口腔医学]