脑动脉硬化与脑梗死病人认知电位P300的检测  

OBSERVATION OF THE COGNITIVE POTENTIAL P300 IN PATIENTS WITH CEREBRAL ARTERIOSCLEROSIS AND WITH CEREBRAL INFARCTION

作　　者：崔红波[1] 郭宗君[1] 王鲁民[2] 

机构地区：[1]青岛大学医学院脑血管病研究所,山东青岛266003 [2]青岛大学医学院第二附属医院神经内科

出　　处：《齐鲁医学杂志》2004年第1期29-30,共2页Medical Journal of Qilu

基　　金：山东省教育厅科研基金资助项目 (J96K5 4)

摘　　要：①目的　观察脑动脉硬化 (CAS)及脑梗死病人认知电位P30 0变化特点及意义。②方法　对CAS组、脑梗死 <2周组 (A组 )、脑梗死 6月～ 4年组 (B组 )、对照组认知电位P30 0进行检测。③结果　CAS组、A组、B组与对照组相比P30 0潜伏期均显著延长 (F =8.6 93,q =8.2 4 0～ 9.796 ,P <0 .0 1) ,B组与CAS组比较P30 0潜伏期显著延长 (q =4 .2 6 8,P <0 .0 5 ) ;A组和B组P30 0波幅均显著小于对照组 (F =4 .985 ,q =4 .310、4 .6 93,P <0 .0 5 )。④结论　脑动脉硬化和脑梗死病人均存在认知电位P30 0异常 ,脑梗死病人随病程延长表现为加重趋势。ObjectiveTo observe the changes and clinical significance of cognitive potential P300 in patients with cerebral arteriosclerosis(CAS) and with cerebral infarction(CI).MethodsTwenty-two cases were included in CAS group. The patients in CI group were subdivided into two groups: Group A(21 cases, 2 weeks of infarction), and Group B(20 cases, 6 months to 4 years). There were 30 cases in the control group. All cases were checked with P300. ResultsThe P300 incubation period in Groups A and B was remarkably longer than that of the control group (F=8.693, q=8.240-9.796, P<0.01). The period in Group B was significantly longer than the CAS group (q=4.268, P<0.05). The wave amplitude of P300 in Groups A and B were significantly shorter than the control group (F=4.985, q=4.310,4.693, P<0.05 ). Conclusion The abnormal cognitive potential P300 exists in both the CAS and CI patients, and the CI patients tend to become more serious with the progress of the disease. [

关 键 词：脑动脉硬化 脑梗死 认知电位 P300 检测 

分 类 号：R743.33[医药卫生—神经病学与精神病学]