在体大鼠脑梗塞区细胞外Na^+、K^+、Ca^(++)浓度动态观察  

The dynamically changes of the concentrations of extracellular Na^+,K^+ and Ca^+ in cerebral infarct areas of the rats in vivo.

作　　者：耿东进[1] 赵瑜[2] 成柏华[3] 

机构地区：[1]上海第二医科大学仁济医院神经科 [2]上海第二医科大学 [3]上海第二医科大学统计医学中心

出　　处：《中国神经精神疾病杂志》1992年第4期199-201,共3页Chinese Journal of Nervous and Mental Diseases

摘　　要：本实验用雄性Wistar大白鼠建立局灶性脑梗塞动物模型。用离子选择性微电极动态检测大鼠正常脑皮层及大脑中动脉凝闭后脑梗塞区细胞外Na^+、K^+、Ca^(++)浓度变化。结果显示:大脑中动脉凝闭后1～2分钟脑梗塞区细胞外Na^+浓度迅速从正常平均浓度138.45±10.64mM(X±SD)降至127.5±10.98mM,K^+浓度从4.72±0.38mM升到6.00±1.10mM,Ca^(++)浓度从1.23±0.05mM降到1.19±0.06mM,并随着脑梗塞时间延长Ca^(++)浓度逐渐下降。In our experiment,the model of focal cerebral infarction in Wistar's rats was replicated by occluding the left middle cerebral artery (MCAO) transcranially.The concentrations of extracellular Na+,K+ and Ca++ in both normal cerebral cortex and the infarct areas of the rats in vivo were measured dynamically with Ion-Selective Microelec-trodes (ISMs).The results showed that the concentrations of extracellular Na+,K+ and Ca++ in the infarct areas changed from 138.45±10.64 mM to 127.5±10.98 mM,4.72±0.38 mM to 6.00±1.10 mM,and 1.23±0.05 mM to 1.19±0.06mM respectively after MCAO 1-2 minutes.Ca++ concentration declined slowly as the time of infarct prolonged.

关 键 词：脑栓塞 钠离子 钾离子 钙离子 

分 类 号：R743.330.2[医药卫生—神经病学与精神病学]