大脑原始神经外胚层肿瘤的临床与病理分析  

Clinical and Pathological Characteristics of Primitive Neuroectodermal Tumor of the Cerebral

作　　者：傅军[1] 周幽心[1] 徐峰[1] 叶明[1] 周岱[1] 鲍耀东[1] 康苏娅[2] 

机构地区：[1]苏州大学附属第一医院神经外科,江苏苏州215006 [2]苏州大学附属第一医院病理科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2004年第1期71-72,共2页Suzhou University Journal of Medical Science

摘　　要：目的　分析大脑原始神经外胚层肿瘤的临床与病理特点。方法　使用光镜、免疫组化和临床资料对 7例大脑原始神经外胚层肿瘤进行观察和分析。结果　 7例中 5例为儿童和青少年 ,病程短且颅内高压症状突出 ;肿瘤组织由小圆形细胞构成 ;免疫组化 :NSE阳性 5例 ,Syn阳性 1例 ,CD99阳性 2例 ,Vimentin阳性 1例 ,GFAP、S 10 0均为阴性 ;CT表现为混合密度或均匀高密度肿块 ,MRI呈长T1、长T2信号。结论　大脑原始神经外胚层肿瘤的临床预后极差 。Objective To study the features of the cerebral primitive neuroectodermal tumor (PNET) in the clinical manifestation and in the histogenesis, morphology. Methods Seven cases of cerebral PNET was analyzed with their clinical manifestations, histologic and immunohistochemical results. Results Five patients of this group were children or young adults. Seven tumors were composed of primitive cells with folcal evidence of glial or neuronal differentiation. Five out seven expreesed NSE, one out seven expressed Syn, two out seven expressed CD99 and only one case expressed Vimentin. None expressed GFAP and S? 100. CT findings were a homogeneous high density or heterogeneous mas. MR findings were high signal intensity both on T1 and T2 images. Conclusion To diagnose the cerebral PNET depends on pathology and cerebral PNET have poor prognosis.

关 键 词：大脑 原始神经外胚层肿瘤 临床 病理 

分 类 号：R739.41[医药卫生—肿瘤]