西比灵长程给药治疗脑梗死和预防其再发的研究  

Study on treatment and preventing the attack again of cerebral infartcion in taking sibelium long term

作　　者：薛彦忠[1] 黄宝荣[1] 聂成福[1] 项建平[1] 郭仕峰[1] 李丽[1] 

机构地区：[1]山东省临沂市沂水中心医院神经内科,276400

出　　处：《临床神经病学杂志》2004年第2期102-104,共3页Journal of Clinical Neurology

摘　　要：目的　探讨西比灵长程给药治疗脑梗死和预防其再发的效果及其机制。方法　 2 39例脑梗死患者随机分为防治组 12 0例 ,对照组 119例。两组常规治疗相同 ,防治组在常规治疗的基础上给予西比灵 10mg,每晚 1次 ,至少半年以上。观察两组治疗 1个月的临床疗效和 1年内的再发率 ,并于治疗前和治疗后 1年 ,分别进行血液流变学、血脂和血小板聚集率检查。结果　防治组在治疗 1个月的显效率为 80 % ,总有效率为 98.3% ,明显高于对照组的 5 4 .6 %和 74 .7% (均P <0 .0 1) ;1年内的再发率为 5 .83% ,明显低于对照组的2 6 .89% (P <0 .0 1)。与脑梗死再发有关的血黏度、血脂、纤维蛋白原及血小板聚集率等指标防治组也明显低于对照组 (均P <0 .0 1)。结论　西比灵长程给药不仅可提高疗效而且可有效预防脑梗死再发 ,其机制可能与降低血脂、抑制血小板聚集和改善血液流变学指标有关。Objective To explore the effect and mechanism of taking sibelium long term for treatment and preventing the attack again of cerebral infartcion.Methods 339 patients with cerebral infarction were divided into 2 groups randomly,namely preventing group(120 cases) and control group(119 cases).The basic treatment in the two groups are the same.The preventing group was taken siblium 10 mg once every evening,at least 6 months.To observe the clinical effect in 1 month and the rate of attack again in 1 year.The two groups were measured on hemorrheology,blood lipid and platelet aggregation rate before and after treatment one year.Results After treatment one month,the significant effective rate in sibelium preventing group is 80%,the total effective rate is 98.3%,but the control group is 54.6% and 74.8%(all P<0.01);the rate of attack again in one year is 5.83%,the control group is 26.89%(P<0.01).And the blood viscosity,blood lipid,fibrin and the platelet aggregation rate relating to attack again of cerebral infarction are lower significantly than the control group(all P<0.01).Conclusion Taking sibelium long term may prevent the attack again of cerebral infarction operatively,the machenism may be relating to decrease blood lipid,anti-platelet aggregation and improve hemorrheology.

关 键 词：西比灵 长程给药 药物治疗 脑梗死 预防 复发 血液流变学 神经功能缺损 

分 类 号：R743.32[医药卫生—神经病学与精神病学]