肉苁蓉总苷对阿霉素所致小鼠心肌线粒体损害的保护作用  

Stereolal study of protective effect of Glycosides of cistanche on mitochondria of cardiac muscle against adriamycin

作　　者：海力曼.依拉洪 邬利娅.伊明 王晓雯[2] 

机构地区：[1]新疆医科大学基础医学院病理教研室,新疆乌鲁木齐830054 [2]新疆医科大学药学院,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2004年第2期128-130,共3页Journal of Xinjiang Medical University

摘　　要：目的:研究肉苁蓉总苷 (GCs)对阿霉素 (ADR)所致小鼠心肌线粒体损害的保护作用。方法:对各实验组小鼠心肌细胞进行超微结构观察 ,并应用体视学方法对心肌细胞的线粒体体密度 (Vvm )、表面积密度 (Svm )、比表面积 (Qm)及线粒体的面数密度 (Num)进行计算。结果:ADR组心肌细胞超微结构有一定程度的损害 ,表现为心肌细胞肿胀 ,线粒体弥漫性肿胀、增生、空泡变性 ;肌浆网扩张 ,次级溶酶体增多 ;核体积增大 ,核周隙增宽。 GCs中高剂量组心肌细胞超微结构基本恢复正常。结论:ADR可导致心肌线粒体的损伤 ,而Objective: To determine the stereologicalparameters change of the cardiac muscle mitochondria in mouse on glycosides of citanche, which protected the cardiac muscle mitochondria against adriamycin (ADR). Methodes: The every group of cardiac muscle Mitochondria was observed by Transmission electrone microscope althor, the volume density (Vvm), surfacedensity (Svm), Qm, numerical density (Num) of mitochondria of the cells were measured, calculated and compared with each other. Results: The cardiac muscle and the mitochondria swollened, with hyperplasia, smooth endoplasmic reticulum expanded. Secondary lysosome increased, the volume of the nuclei expaned Vvm, Svm, Qm, Num of the cardiac muscle were increased (P<0.01). Vvm, Svm, Qm, Num of the Gcs cardiac muscle were decreased to compare with the ADR group (P< 0.01 ) the result indicate that were to protective effect of GCs on mitochondria of cardiac muscle against ADR. Conclusion: mitochondria of the cardiac muscle were damaged by the ADR, GCs have some protective role.

关 键 词：肉苁蓉总苷 阿霉素 心肌细胞线粒体损害 保护作用 体视学 广谱抗肿瘤药物 

分 类 号：R-332[医药卫生] R979.1