骨形态发生蛋白-1及其相关金属蛋白酶  

Bone morphogenetic protein-1 and its related metalloproteinase

作　　者：陈冬瑛[1] 朱全胜[1] 丘钜世[1] 

机构地区：[1]中山大学中山医学院病理学教研室,广东广州510089

出　　处：《中国病理生理杂志》2004年第4期690-694,699,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目 (No .39770 30 1)

摘　　要：Bone morphogenetic protein-1(BMP-1) and its related molecules are members of metalloendoproteinase astacin family, including BMP-1, mTLD, mTLL-1 and mTLL-2. Even though all of them lack of the ability to induce bone or cartilage formation directly, they play key roles in numerable activities in ECM from embryo to adult, then affect the procedure and the result of osteogenesis and bone remodeling directly or indirectly. They are critical in maturation and deposition of some major collagen types, and in regulating the signaling of some growth factors in TGF-β superfamily by degradation of TGF-β inhibitor such as Chordin. The investigations about tissue distribution of BMP-1 and its related proteinases and also gene knock-out studies strongly indicate that they play key roles in osteogenesis and bone development.Bone morphogenetic protein-1(BMP-1) and its related molecules are members of metalloendoproteinase astacin family, including BMP-1, mTLD, mTLL-1 and mTLL-2. Even though all of them lack of the ability to induce bone or cartilage formation directly, they play key roles in numerable activities in ECM from embryo to adult, then affect the procedure and the result of osteogenesis and bone remodeling directly or indirectly. They are critical in maturation and deposition of some major collagen types, and in regulating the signaling of some growth factors in TGF-β superfamily by degradation of TGF-β inhibitor such as Chordin. The investigations about tissue distribution of BMP-1 and its related proteinases and also gene knock-out studies strongly indicate that they play key roles in osteogenesis and bone development.

关 键 词：骨形态发生蛋白质类 胶原 生长物质 金属内肽酶类 

分 类 号：R363[医药卫生—病理学]