平阳霉素治疗口腔颌面部淋巴管瘤235例的临床总结  

The Effect of Pingyangmycin to Treat Lymphangioma in the Oro-maxillo-facial Regions: A Report of 235 Cases

作　　者：寿柏泉[1] 寿卫东[2] 杨震[1] 孟昭业[1] 张森林[1] 曹罡[1] 刘锐[1] 董震[1] 

机构地区：[1]南京军区南京总医院口腔颌面外科,江苏南京210002 [2]南京市口腔医院

出　　处：《口腔医学研究》2004年第2期186-188,共3页Journal of Oral Science Research

摘　　要：目的 :观察平阳霉素 (PYM)瘤内注射治疗口腔颌面部各类淋巴管瘤 (LPGM)的疗效 ,以指导临床对不同类型LPGM采用不同的治疗方法。方法 :收集 1996年 1月至 2 0 0 3年 6月 ,用PYM注射治疗口腔颌面部毛细管型、海绵状型和囊肿型 (囊性水瘤 )淋巴管瘤 2 35例 ,男性 12 9例 ,女性 10 6例。用 1%普鲁卡因 8mL ,配PYM 8mg ,按体表瘤体面积每 1cm× 1cm注射 1mL混合药液计算剂量 ,进行瘤体内注射。 7～ 10d注射 1次 ,3～ 8次为一个疗程。结果 :经 6个月至 7年随访治愈来愈例 (85 .5 3% ) ,好转 2 4例 (10 .2 1% ) ,总有效率为 95 .74 %。其中毛细管型 ,海绵状型和囊肿型LPGM的治愈率分别为 80 .33%、88.0 0 %、93.37%。结论 :PYM治疗口腔颌面部各类LPGM疗效高 ,是一种简便。Objectives: The effect of pingyangmycin (PYM) in treatment of lymphangioma (LPGM) in the oro-maxillofacial regions is evaluated. Methods: The medical records of 235 patients with LPGM in the oro-maxillofacial regions between January 1996 and June 2003 were reviewed.One hundred and Twenty-nine of the patients were men, and 106 were women, the sex ratio was 1:0.82. The patients' ages were between 3 months and 33 years. The size of the lesions varied from 1.5 cm×2 cm to 11 cm×20 cm.PYM was injected into the cavity in the LPGM and the injected may be repeated every 7～10 days. This process may be repeated 3～8 times. Results: Two hundred and thirty-five patients were followe for 6 months～7 yesrs.The cured rate were 85.53% getting improvement was 10.21%. The total efficiency was 95.74%. The cured rates of capillary type lymphangioma, cavenous type lymphangioma and cystic type lymphangioma were 80.33%, 88.00% and 97.37% respectively. Conclusions: This method may be a safe, simple and effective therapy to the capilary LPGM, cavernous LPGM and cyst LPGM in the oromaxillofacial regions.

关 键 词：平阳霉素 口腔颌面部 淋巴管瘤 临床分型 化疗 适应征 

分 类 号：R739.8[医药卫生—肿瘤]