人肝细胞癌VEGF及受体的表达与临床病理的关系  

Relationship between Expression of VEGF、flk-1、flt-1 Protein and Clinicopathology in Hepatocellular Carcinoma

作　　者：郝继辉[1] 李强[1] 俞鸣[2] 焦振山[2] 史玉荣[3] 郝希山[4] 

机构地区：[1]山天津医科大学附属肿瘤医院肝胆肿瘤科,天津市300060 [2]天津医科大学公共卫生学院 [3]天津市肿瘤研究所中心实验室 [4]天津医科大学附属肿瘤医院肝胆肿瘤科,天津市300060

出　　处：《中国肿瘤临床》2004年第3期127-130,共4页Chinese Journal of Clinical Oncology

基　　金：天津市自然科学基金资助(编号:013615611)

摘　　要：目的:分析VEGF及其受体flt-1/flk-1蛋白表达与肝细胞癌临床病理的关系。方法:应用ABC免疫组化染色法,检测60例肝细胞癌中VEGF、flk-1、flt-1蛋白表达情况,并分析它们与肝细胞癌临床病理的关系。结果:60例肝细胞癌组织中VEGF、flk-1、flt-1蛋白的阳性表达率分别为81.3%、88.3%、80.0%,均明显高于正常肝组织(P<0.05);并且VEGF蛋白表达与肿瘤的病理分级、有无包膜、瘤栓、直径大小均有相关性。结论:VEGF蛋白表达水平越高,细胞恶性程度及侵袭、转移能力越强,并且VEGF与flt-1/flk-1在肿瘤形成过程中具有协同作用。Objectives: To study the relationship between expression of VEGF、flk-1、flt-1 protein and clinicopathology in hepatocellular carcinoma. Method: The expression of VEGF、flk-1、flt-1 protein in 60 patients with hepatocellular carcinoma were detected by immunohistochemistry (ABC method) and the relationship between expression of VEGF protein and its clinicopathology was evaluated. Results: The positive rates of VEGF、flk-1、flt-1 protein were 81.3%、88.3%、80.0% in tumor tissues, respectively, and they were significantly higher than that in normal liver tissue (P<0.05). The expression of VEGF protein was correlated with the histologic grade, metastasis of tumor. Conclusion: The results showed that the higher expression of VEGF protein was associated with the higher malignant degree and more chances of metastasis in hepatocellular carcinoma. VEGF、flk-1、flt-1 play an important role in tumourgenesis.

关 键 词：肝细胞癌 VEGF FLK-1 FLT-1 临床病理 

分 类 号：R735.7[医药卫生—肿瘤]