低剂量^(103)Pd支架抑制TIPSS分流道狭窄初探  

Experimental Studies of Prevention of TIPSS Shunt Stenosis With Low Dose ^(103)Pd Stents

作　　者：高沁怡[1] 张曦彤[2] 舒强[3] 李亚明[1] 裴著果[4] 许书河[5] 

机构地区：[1]中国医科大学附属第一医院核医学科 [2]中国医科大学附属第一医院放射介入科 辽宁沈阳 1 1 0 0 0 1 [3]中国医科大学附属第一医院局解手术学教研室 [4]中国医科大学附属第二医院核医学科 [5]中国原子能科学研究院同位素研究所

出　　处：《同位素》2004年第1期47-50,共4页Journal of Isotopes

基　　金：辽宁省教育厅科研基金资助项目(202013157)

摘　　要：探讨103Pd支架预防经静脉肝内门腔静脉内支架分流术(TIPSS)分流道狭窄的效果。健康乳猪18只行TIPSS,术后分为两组,分别置入103Pd支架和普通支架。并于术后4周、8周行血管造影、病理解剖和光镜管腔面积检测。门静脉造影显示4周时放射组2例、对照组3例狭窄;8周时放射组全部闭塞,对照组部分狭窄。术后4周肝实质段支架内径组织增生厚度(12.95MBq组)为3.64±1.01mm,对照组增生厚度为2.24±1.02mm,两组差异明显(P<0.05)。由此表明,9.25和12.95MBq103Pd支架均未能抑制TIPSS分流道术后狭窄。To evaluate the role about prevention of shunt stenosis after TIPSS by ^(103)Pd stents, ^(103)Pd stents and general stents are placed respectively in 18 healthy swines which in the two groups at 4, 8 weeks after TIPSS, are made angiography, pathological dissection and inspection of lumen area by light microscope. The results show that stenosis appears in 2 cases of radiation group and 3 cases in control group at 4 weeks. Obstructon appears in all of radiation group and partly stenosis appeared in 2 cases of radiation group and 3 cases in control group at 4 weeks. and in all of radiation group and partly stenosis appears in control group at 8 weeks. Thickness of vascular wall of hepatic vein segment in scope of stents is 3.64±1.01 mm in radiation group(12.95 MBq) and 2.24±(1.02) mm in control group. Difference between two groups is evidenced (P<0.05). 9.25 and 12.95 MBq^(103)Pd stents can not prevent stenoses after TIPSS.

关 键 词：^103Pd支架 分流道狭窄 TIPSS 经颈静脉肝内门腔静脉内支架分流术 铅 

分 类 号：R817.5[医药卫生—影像医学与核医学]