癫痫灶切除加多处软膜下横纤维切断术治疗难治性癫痫  

Resecting the epileptogenic foci combing with multiple subpial transection (MST) for the treatment of the intractable epilepsy

作　　者：匡永勤[1] 顾建文[1] 李开慧[1] 王方[1] 党世华[1] 王明花[1] 李亚东[1] 

机构地区：[1]成都军区总医院神经外科癫痫诊治中心,成都610017

出　　处：《立体定向和功能性神经外科杂志》2004年第2期82-84,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的　探讨癫痫灶切除辅以多处软膜下横纤维切断术 (multiplesubpialtransections,MST)对难治性癫痫治疗的临床效果。方法　 5 2例难治性癫痫 ,通过癫痫灶切除加多处软膜下横纤维切断术 4 8例 ,癫痫灶切除加多处软膜下横纤维切断和胼胝体前 1/ 3潜行切开 4例。对术后早期和 9～ 30个月临床随访观察。结果　术后早期可见 6例一过性肢体肌力减弱 ,11例一过性失语 ,均在 5～ 10天内恢复 ,5 2例手术后随访 9～ 30个月 ,完全无发作 33例 ,发作次数减少 80 %以上 10例 ,发作减少 5 0 %以上 6例 ,3例发作次数及发作持续时间与症状明显减轻。Objective To investigate the clinical effect on epileptogenic lesionectomy combing with multiple subpial transection (MST) for the intractable epilepsy.Methods 52 patients with intractable epilepsy were treated by surgery in our department from 1999～2003,48 cases were performed with epileptogenic lesionectomy with MST;4 patients with resecting the epilepetogenic focus,MST and pre 1/3 corpus callosotomy.follow-up was accomplished in 52 patients for a duration of 9～30 months and in the early postoperative period.Results Dyspraxia in 6 patients,transient aphasia in 11 patients had recovered in 5～10 days postoperation.Seizure disappeared completely in 33 cases,decreased significantly (>80%)in 10 cases,decreased moderately (>50%) in 6 cases,and decreased slightly (>50%) in 3 cases.The total effective rate was 94.2%.Conclusions Resecting the epilepetogenic focus combing with MST is an effective and safe treatment for the intractable epilepsy.

关 键 词：癫痫灶切除术 多处软膜下横纤维切断术 外科治疗 难治性癫痫 胼胝体切开术 

分 类 号：R742.1[医药卫生—神经病学与精神病学]