线刺法蛛网膜下腔出血动物模型制备  

Preparation of animal model of subarachnoid hemorrhage

作　　者：陈德森[1] 郭俐宏[2] 罗超[1] 彭吉霞[1] 郭锐[1] 

机构地区：[1]郧阳医学院机能实验室,湖北十堰442000 [2]太和医院针灸科,湖北十堰442000

出　　处：《大连医科大学学报》2004年第1期44-46,共3页Journal of Dalian Medical University

摘　　要：[目的 ]线刺法建立可真实模拟蛛网膜下腔出血 (SAH )的动物模型。 [方法 ]大鼠经右侧翼腭动脉线刺法刺破Willis环的血管分叉处 ,造成Willis环血管破裂出血后动态观测局部脑血流(rCBF)及脑电图 (EEG)的变化。 [结果 ]蛛网膜下腔出血 (SAH )后rCBF及EEG幅度急剧下降 ,分别下降为 4 0 .5 %和 6 8.6 % ,30minSAH组rCBF下降幅度最大 (6 2 .3% ) ,EEG 1 5min下降幅度最大 (89.5 % )。rCBF下降持续 4 8h ,颅底解剖学检查发现Willis环的血管分叉处有陈旧性出血。 [结论To prepare the animal model of subarachnoid hemorrhage(SAH). The fork of Willis ring was pierce with a line through right pterygopalatine artery to dynamically record the change in regional cerebral blood flow(rCBF) and electroencephalograph(EEG). At piercing the rCBF and EFG dropped rapidly by 40.5% and 68.6% respectively . At 30 min rCBF dropped to bottom by 62.3% and at 15 min EFG by 89.5%.the drop of rCBF lasted 48 hours. Basicranial anatomy showed remote hemorrhage at the fork of Willis ring. [Conclusion] The model is reliable in simulating SAH.

关 键 词：蛛网膜下腔出血 脑血流 脑电图 

分 类 号：R-332[医药卫生]