细胞周期调节蛋白D_1表达与宫颈癌关系的研究  

Expression of Cyclin D_1 and its Involvement in Carcinogenesis of Cervical Carcinoma

作　　者：张桓[1] 张建中[2] 于黎明[1] 韩恩善[2] 霍正浩[3] 

机构地区：[1]宁夏医学院附属医院妇产科,银川750004 [2]宁夏医学院附属医院病理科,银川750004 [3]宁夏医学院附属医院生物学教研室,银川750004

出　　处：《宁夏医学院学报》2004年第1期11-13,共3页Journal of Ningxia Medical College

摘　　要：目的 :观察细胞周围调节蛋白 (Cyclin)D1 在宫颈癌组织中的表达并探讨其意义。方法 :应用SP免疫组化法检测 11例正常宫颈上皮 ,9例宫颈上皮内瘤样病变 (CIN)和 4 8例宫颈癌石蜡包埋组织切片中CyclinD1 基因蛋白表达情况。结果 :正常宫颈上皮、CIN和宫颈癌组织 ,CyclinD1 表达的阳性率分别为 9 0 9%、33 33%、4 1 6 7% ;从正常宫颈到CIN到宫颈癌组织中CyclinD1 表达呈现逐渐升高的趋势。宫颈癌组织CyclinD1 表达明显高于正常宫颈上皮 (P <0 0 5) ,CIN和正常宫颈上皮比较 ,CyclinD1 表达无显著性差异 (P >0 0 5)。CyclinD1 表达与宫颈癌的临床分期、组织类型、分化程度以及淋巴结转移均无显著相关性 (P >0 0 5)。结论 :CyclinD1Objective: This study was to elucidate the expression of cells regulato r Cyclin D 1 in normal cervix, CIN, and its implication in the genesis of cervi cal carcinoma Methods: Immunohistochemical method was used to deter mine the Cyclin D 1 expression level in 11 paraffin sections in normal cervix, 9 in CIN, and 48 in cervical carcinoma Results: The positive rate of Cyclin D 1 e xpre ssion was 9 09% of normal cervix, 33 33% of CIN , and 41 67% of cervical carc ino ma, respectively Cyclin D 1 expression increased gradually from 9 09% in the norm al cervix to 41 67% in cervical carcinoma Cyclin D 1 expression in cervical c arcin oma was significantly higher than that in normal cervix No statistical correla t ion was observed between Cyclin D 1 expression and other clinical data in patie nts with cervical carcinoma Conclusion: These data suggested that t h e Cyclin D 1 expression was involved in the carcinogensis, development, and pro gression of cervical carcinoma

关 键 词：细胞周期调节蛋白D1 表达 宫颈癌 宫颈上皮内瘤 

分 类 号：R737.33[医药卫生—肿瘤]