丙型肝炎病毒感染至临床诊断肝癌的病程经过  

Course analysis: from HCV infection to hepatocellular carcinoma

作　　者：王晓峰[1] 程勇前[1] 张文瑾[1] 赵平[1] 黄艳玲[1] 

机构地区：[1]北京中国人民解放军第三○二医院感染五科,100039

出　　处：《肝脏》2004年第1期8-10,共3页Chinese Hepatology

摘　　要：目的　探讨丙型肝炎病毒 (HCV)感染发展为肝硬化、肝细胞癌的平均临床病程。方法　收集我院收治的73例感染HCV的肝癌患者病例资料 ,对其从HCV感染发展为慢性肝炎、肝硬化和肝癌病程经过进行统计学分析。结果　输血至临床诊断为肝癌的平均时间为 ( 2 0 .83± 11.63 )年 ,临床诊断慢性丙型肝炎至肝硬化平均时间为 ( 11.91± 11.0 6)年 ;慢性肝炎发展为肝癌的平均时间为 ( 12 .2 1± 11.90 )年 ,肝硬化至临床诊断肝癌 ( 3 2例 )平均病程为 ( 3 .0 3± 2 .84)年。结论　HCV感染发展为肝细胞癌的病程进展缓慢 ,有输血史的患者较无输血者平均病程短。Objective To study the course from HCV infection to the development of hepatocellular. carcinoma and related factors.Methods 73 hepatocellular carcinoma patients with HCV infection were included. The course from HCV infection to liver cirrhosis and hepatocellular carcinoma,the influence of associated HBV infection and alcoholic liver disease to the course were analyzed. Results The mean interval between the date of blood transfusion and hepatocellular carcinoma was 20.83±11.63 years. The mean interval between diagnosis of chronic hepatitis C and liver cirrhosis was 11.91±11.06 years, and that of hepatocellular carcinoma was 12.21±11.90 years. The mean interval between diagnosis of liver cirrhosis and hepatocellular carcinoma was 3.03±2.84 years. Conclusion The progress from HCV infection through cirrhosis and hepatocellular carcinoma was slow. The progress was faster in patients with blood transfusion history than those without.

关 键 词：丙型肝炎病毒感染 诊断 肝癌 病程 肝硬化 

分 类 号：R735.7[医药卫生—肿瘤]