白血病细胞ras癌基因产物P_(21)的免疫细胞化学研究  

IMMUNE STUDY ON RAS ONCOGENE PRODUCT P_(21) IN LEUKEUMIC CELLS

作　　者：董文瑞[1] 高鹏远[1] 王岩[1] 刘卓刚[1] 吕攸华 董文翰[2] 贾心善[3] 裴惠敏[3] 

机构地区：[1]中国医科大学附属第二医院内科 [2]中国医科大学附属第二医院儿科 [3]中国医科大学基础医学部病理解剖学教研室

出　　处：《中国医科大学学报》1992年第3期202-204,共3页Journal of China Medical University

摘　　要：采用ras癌基因产物P_(21)的单克隆抗体对26例白血病骨髓涂片进行免疫细胞化学研究。结果表明:粒细胞白血病为阳性,且较正常白细胞ras癌基因P_(21)表达明显增高。在幼稚的粒细胞分化阶段,P_(21)表达亦增高。淋巴细胞白血病为阴性。我们认为,ras癌基因与细胞增殖可能有密切关系。并可能在粒细胞白血病的成因上,较淋巴细胞白血病占有更重要的位置。Immunocytochemical study was carried out on the bone marrow smears of 26 patients with leukemia with the use of monoclonal antibody against ras oncogene product P_(21).The results showed; It was positive in granulocytic leukemia and negative in lymphatic leukemia.The expression of ras oncogene product P_(21) was more prominant in granulocytic leukemia than that in normal granulocyte and was also increased during the differentiation stage of premature granulocyte. Thus, we conclude that ras oncogene might closely correlated with cell proliferation and play a more important role in the development of granulocytic leukemia than that in lymphatic leukemia.

关 键 词：免疫细胞化学 白血病 

分 类 号：R733.703[医药卫生—肿瘤]