~1H MRS在常见脑肿瘤诊断中的初步应用  

Application of 1H MR Spectroscopy in the Diagnosis of the Intracranial Tumor

作　　者：齐志刚 沈天真 陈星荣 

机构地区：[1]复旦大学附属华山医院放射科,200040

出　　处：《中国医学计算机成像杂志》2004年第1期8-14,共7页Chinese Computed Medical Imaging

摘　　要：目的:分析磁共振波谱在胶质瘤和脑膜瘤中的诊断和鉴别诊断价值。材料和方法:29例患者(胶质瘤16例,脑膜瘤13例)先完成常规平扫,后均行PRESS序列行单体素波谱检查,部分同时进行STEAM序列检查。结果:胶质瘤组的病灶侧和对侧的NAA/Cr之间有显著性差异(P<0.01),病灶侧Cho/Cr以及Cho/Creontra和对侧Cho/Cr之间有差异(P<0.05);mI/Crcontra在高度恶性和低度恶性胶质瘤之间有差异(P<0.05)。脑膜瘤组的波谱在1.4×10-6～1.6×10-6处可见倒置的Ala双峰,良性和恶性脑膜瘤的Cho/Crcontra比较有差异(P<0.05);NAA/Cr在恶性脑膜瘤瘤周1cm处的水肿区与对侧比较有差异。结论:mI/Cr可以作为低度和高度恶性胶质瘤的分级指标,Lip可能在胶质瘤的分级中有意义。Ala可以作为脑膜瘤的诊断标志,Cho/Crcontra在脑膜瘤的良、恶性分级中有意义。Purpose: To analyze the value of MR Spectroscopy in the diagnosis of the intracranial tumor as the glioma and the meningioma.Materials and Methods: All the twenty nine patients(16 cases of the glioma, 13 cases of the meningioma) had underwent MR routine scanning and MR spectroscopy. After the plain MR scan of the head, single voxel PRESS was used in all patients while the STEAM was used in partial patients at the same time. Results: The difference in NAA/Cr. Cho/Cr and Cho/Crcontra was statistically significant between the area of the lesion and the central side. The difference in mI/ Cr-contra was statistically significant between Ⅰ-Ⅱand Ⅲ-Ⅳ gliomas. The peak of Ala between 1.4 ×10-6-1.6×10-6 can be seen in all the meningiomas. The difference in Cho/Crcontra was statistically significant between the benign and the malignant menigiomas. Conclusion: The ratio of ml/Cr can be considered as the standard to classify the malignancy of glioma and Lip may be valuable in it.Ala can be treated as the symbol in the diagnosis of meningioma. The ratio of Cho/Crcontra is valuable in the grading between benign and malignant meningioma.

关 键 词：HMRS 脑肿瘤 诊断 磁共振波谱分析 

分 类 号：R739.4[医药卫生—肿瘤]