磁共振灌注成像在脑转移瘤伽玛刀疗效评估中的应用  

Application of MR Perfusion-weighted Imaging in the Evaluation of Therapeutic Effect of Brain Metastases with Gamma Knife

作　　者：董海波[1] 戴嘉中[2] 沈天真[2] 徐海东[1] 俞振浩[1] 

机构地区：[1]浙江省宁波市医疗中心李惠利医院放射科,浙江宁波315040 [2]复旦大学华山医院放射科

出　　处：《实用放射学杂志》2004年第4期302-305,共4页Journal of Practical Radiology

摘　　要：目的　评估磁共振灌注成像 (PWI)在脑转移瘤伽玛刀疗效中的应用价值。方法　 2 2例脑转移瘤伽玛刀治疗前及治疗后 3、6个月以上行PWI。得到相对局部脑血容量 (rCBV)图和对比剂平均通过时间 (MTT)图 ,计算病灶rCBV和MTT比率。结果　 2 2例脑转移瘤的rCBV值均升高 ,肿瘤rCBV比率为 6.16± 3 .12 ,健侧为 1.18± 0 .17;肿瘤MTT比率为 1.44± 0 .5 3。 9例治疗后rCBV比率下降 ,MTT比率无变化 ,其中 3例证实为放射性脑坏死。 13例治疗后rCBV比率不同程度升高 ,其中 6例证实为肿瘤伴部分坏死组织。Objective To investigate the value of MR perfusion-weighted imaging(PWI)in the evaluation of therapeutic effect of brain metastases with gamma knife.Methods Treatment by gamma knife before and after that 3 months or 6 months PWI studies were penformed respectively in 22 patients with brain metastases .Maps of relative regional blood volume(rCBV)and mean transit time(MTT)were obtained.The ratios of rCBV and MTT of lesions were analyzed.Results rCBV of tumors in 22 cases was increased.The ratios of maximum rCBV of the lesions and opposite side were 6.16±3.12 and 1.18±0.17 respectively.The ratios of MTT of the tumors was 1.44±0.53.After gamma knife treatment,9 of 22 cases appeared decreased rCBV,but the ratios of MTT were no changing,of them,3 cases presented cerebral necrosis.13 of 22 cases,the ratios of rCBV were increased in varied degree after treatment by gamma knife,and 6 cases presented brain radionecrosis.Conclusion PWI is a significant method in evaluating the therapeutic effect of brain metastases with gamma knife

关 键 词：磁共振 灌注成像 脑转移瘤 伽玛刀 肿瘤 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]