白细胞介素1受体拮抗剂基因型与维吾尔族慢性牙周炎的关系  

The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients

作　　者：钟良军[1] 张蕴惠[2] 章锦才[3] 冯锦虹[1] 杨爱玲[2] 

机构地区：[1]新疆医科大学第一附属医院口腔科,乌鲁木齐830054 [2]四川大学华西口腔医学院牙周科 [3]广东省口腔医院牙周科

出　　处：《中华口腔医学杂志》2003年第5期370-373,共4页Chinese Journal of Stomatology

摘　　要：目的　探讨白细胞介素 1受体拮抗剂 (interleukin 1receptorantagonist,IL 1ra)基因型与新疆维吾尔族慢性牙周炎 (chronicperiodontitis,CP)易感性的关系。 方法　收集维吾尔族重度CP患者 4l例、中度CP 4 3例、轻度CP 4 9例及同族健康对照 92人的颊粘膜拭子 ,提取DNA ,采用序列特异引物多聚酶链反应 (sequencespecificprimers polymerasechainreaction ,SSP PCR)法测定IL 1RN内含子 2 /VNTR位点的基因型 ,比较各基因型检出率的差别。结果　IL 1RN内含子 2 /VNTR等位基因2在重度CP中的检出率显著高于对照组 ,而在中度CP与对照组、轻度CP与对照组间的分布差异无显著性。结论　IL 1RN内含子 2 /VNTR等位基因Objective To investigate interleukin-1 receptor antagonist (IL-1ra) genotype and its association with the susceptibility of chronic periodontitis in Uighur patients of Xinjiang. Methods Genomic DNA was obtained from buccal swabs of 41 subjects with severe chronic periodontitis(CP), 43 subjects with moderate CP, 49 subjects with mild CP and 92 ethnically matched healthy control individuals. Genotypes of IL-1RN intron 2 VNTR was analyzed by SSP-PCR method. Then compared the differences in distribution of each genotype. Results A significant over-representation of IL-1RN intron 2 VNTR allele 2 was found in severe chronic periodontitis group. Conclusion IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of severe chronic periodontitis in Uighur patients of Xinjiang.

关 键 词：白细胞介素1受体拮抗剂 基因型 维吾尔族 慢性牙周炎 IL-1RA 疾病易感性 

分 类 号：R781.4[医药卫生—口腔医学]