上皮性卵巢癌放射免疫药盒的制备和临床应用  

The Preparation and Clinical Use of a Radioimmunoassay CA_(125) Kit for the Diagnosis of Epithelial Ovarian Cancer

作　　者：刘文淑[1] 卞美璐[1] 郁茵华 杨子义[1] 许秀英[1] 连利娟[1] 

机构地区：[1]中国医学科学院协和医院

出　　处：《中国医学科学院学报》1992年第6期469-472,共4页Acta Academiae Medicinae Sinicae

摘　　要：卵巢癌是女性生殖系统肿瘤发病率居第三位,死亡率第一位的疾病。为提高治愈率,准确的诊断和监测是非常重要的.从免疫学角度,国外已制备了数种放射免疫药盒,但效果满意的仅有美国的CA_(125)药盒。国内目前尚无相应药盒.我室从1989年开始自行制备CA_(125)药盒,用于诊断和监测上皮性卵巢癌效果与美国的CA_(125)药盒相同。A self-made radioimmunoassay CA125 kit (using OC125 monoclonal antibody ascites offered by Dr. Bast Laboratory which, was purified, solidified and labelled with 125I) was used for serum determination in 80 patients with epithelial ovarian cancer and in 40 standard antigen samples. The results demonstrated a statistically significant correlation between our self-made CA125 kit and an imported CENTOCOR CA125 kit (P<0.001).Clinical experience before operation in 40 patints with epithelial ovarian cancer, 34 with endometriosis and 39 with other malignant ovarian tumors suggested that the self-made CA125 kit was more sensitive in diagnosing epithelial ovarian cancer than the other two diseases. Post-operative follow-up in 86 nonrecurrent cases and 101 recurrent cases showed a 96% positive predictive rate and 91% negative predictive rate. It is concluded that self-made CA125 kit is very useful in monitoring epithelial ovarian cancer.

关 键 词：卵巢肿瘤 放射免疫测定 试剂盒 

分 类 号：R737.310.4[医药卫生—肿瘤]