岩斜脑膜瘤的伽玛刀治疗  

Gamma Knife radiosurgery of petroclival area meningiomas

作　　者：罗斌[1] 刘阿力[1] 王忠诚[1] 王美华[1] 孙时斌[1] 刘鹏[1] 

机构地区：[1]北京市神经外科研究所伽玛刀室,北京100050

出　　处：《中国微侵袭神经外科杂志》2003年第6期260-262,共3页Chinese Journal of Minimally Invasive Neurosurgery

摘　　要：目的评估伽玛刀治疗岩斜区脑膜瘤的疗效。方法1995～2000年,我们对66例岩斜区脑膜瘤病人进行了伽玛刀治疗,肿瘤体积0.32～29.4cm3,平均(5.87±5.10)cm3。周边剂量为7～14.4Gy,平均(12.4±1.6)Gy;中心剂量16～65Gy,平均(27.9±5.9)Gy。结果60例随访25～94个月,平均(57.8±22.3)个月:肿瘤体积缩小23例(38.3%),不变35例(58.3%),增大2例(3.3%);神经系统症状好转37例(61.7%),稳定20例(33.3%),加重3例(5.0%)。无严重并发症发生。结论伽玛刀治疗能很好地控制肿瘤,副作用轻微,可作为神经外科较大肿瘤的辅助性治疗,也可作为较小肿瘤或不适合手术的病人的主要治疗。Objective To assess the role of the Gamma Knife (GK) in the management of petroclival area meningiomas. Methods From 1995 to 2000, 66 patients of petroclival meningiomas were undergone GK treatment. The treatment volume was between 0.32 to 29.4 cm3 (mean 5.87±5.10). The doses for the tumor margin and center were 7-14.4 Gy (mean 12.4±1.6), 16-65 Gy (mean 27.9±5.9) respectively. Results During the follow-up period of 25-94 months (mean 57.8±22.3), 60 patients' data showed that neurological symptoms improved in 37 patients (61.7%), stable in 20 patients (33.3%), and worsening in 3 patients (5.0%). Tumor volumes decreased in 23 patients (38.3%), stable in 35 patients (58.3%), and increased in 2 patients (3.3%). The related complication or cranial nerve deficit was little and mild. Conclusion The excellent tumor growth control results obtained with minimal associated side effects, suggest that GK is an effective therapeutic tool for treatment of petroclival area meningiomas, either as an adjunct option of neurosurgery for larger tumors or as a primary option for smaller ones or for the patients who weren't suit for surgery.

关 键 词：岩斜区 脑膜瘤 伽玛刀 放射疗法 影像学检查 并发症 

分 类 号：R739.45[医药卫生—肿瘤] R730.55[医药卫生—临床医学]