6-苯基-4,5-二氢-3(2H)-哒嗪酮合成方法改进  

IMPROVED SYNTHESIS OF 6-PHENYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONES

作　　者：徐萍[1] 王书玉[1] 刘维勤[1] 

机构地区：[1]北京医科大学药化教研室,北京100083

出　　处：《中国医药工业杂志》1992年第1期30-31,共2页Chinese Journal of Pharmaceuticals

摘　　要：从芳醛、吗啉及氰化钾制得的α-取代苯基吗啉乙腈(2),与丙烯腈1,4-加成,可合成3-芳酰丙酸(5)。5与肼反应可得6-取代苯基-4,5-二氢-3(2H)-哒嗪酮(1)。The α-(substituted-phenyl)morpholinoacetonitriles(2),obtainedfrom aromatic aldehydes,morpholine and potassium cyanide,had been used tosynthesize 3-(aroyl)propionic acids(5)by 1,4-additions to acrylonitrile.5 rea-cting with hydrazine yielded 6-(substituted-phenyl)-4,5-dihydro-3(2H)-pyridazi-nones(1).

关 键 词：哒嗪酮 合成 3-芳酰丙酸 

分 类 号：TQ463.24[化学工程—制药化工]