不同剂量糖皮质激素联合阿昔洛韦治疗带状疱疹的疗效观察  

Application of different doses of glucocorticoids combined with acyclovir to the treatment of patients with acute herpes zoster.

作　　者：黄巍[1] 樊超[1] 涂亚庭[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《华中医学杂志》2004年第2期101-102,共2页Central China Medical Journal

摘　　要：目的　观察不同剂量的糖皮质激素联合阿昔洛韦治疗老年急性带状疱疹的疗效。方法　观察组 (A组 ) 5 0例采用小剂量激素 (泼尼松每天 15mg)联合阿昔洛韦治疗 ,两个对照组分别为B组 5 0例及C组 4 6例 ,使用较大剂量激素 (泼尼松每天 30mg和每天 6 0mg)联合阿昔洛韦治疗。其他治疗措施及方法基本相同。 结果　A组在止疱时间、疱疹消退时间及疱疹后神经痛 (PHN)发生率上与B、C组均无显著性差异 (P >0 .0 5 )。结论　对无禁忌证的老年急性带状疱疹患者早期应用小剂量糖皮质激素 (泼尼松每天 15mg)辅助治疗 ,可收到较好疗效 。Objective To compare the therapeutic effects of applying different doses of glucocorticoids to patients with acute herpes zoster.Methods 50 cases in the treatment group were treated with low dose glucocorticoids(prednisone,15 mg/d),and two others control group containing 50 cases and 46 cases respectively were treated with high doses glucocorticoids(prednisone 30 mg/d and 60mg/d respectively). Other management were alike.Results Intent-to-treat analysis did not detect statistically significant differences for low doses vs high doses glucocorticoids on resolution of zoster-associated pain (P> 0.05). Furthermore, no differences were evident between treatments on rash healing time and on prevalence of postherpetic neuralgia(P> 0.05). Conclusion To start therapy with low dose glucocorticoids(prednisone15 mg/d) and antiviral agent as soon as possible is effective in treating patients older than 50 years of age with acute herpes zoster and can avoid some possible side effects cause by the application of high dose glucocorticoids.

关 键 词：剂量 糖皮质激素 阿昔洛韦 治疗 带状疱疹 胰岛素 

分 类 号：R752.12[医药卫生—皮肤病学与性病学] R977.1[医药卫生—临床医学]