不同剂量氢化麦角碱治疗急性缺血性脑卒中  

Effect of different doses of dihydroergotoxine on acute ischemic stroke

作　　者：张晖[1] 樊东升[1] 张新宇[1] 王力平[1] 张燕[1] 谢汝萍[1] 

机构地区：[1]北京大学第三医院神经内科,北京市100083

出　　处：《中国康复理论与实践》2004年第3期179-180,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中国-斯洛文尼亚政府间科技合作项目 (P0 5 :1 9)

摘　　要：目的观察两种不同剂量氢化麦角碱对急性缺血性脑卒中患者的疗效及安全性。方法采用随机方法将 3 0例急性缺血性脑卒中患者分为 3组 ,每组 10例 ,各组患者分别每日静滴氢化麦角碱 0 .6mg(第 1组 )、1.5mg(第 2组 )或丹参注射液 40ml(第 3组 ) ,疗程 14天。结果 3组治疗前后的斯堪地那维亚脑卒中评分 (SSS)值比较 ,均有非常显著性差异 (P <0 0 5 )。三组相互比较 ,第 1组与第 3组间无显著性差异 (P >0 0 5 ) ,而第 2组与第 3组、第 2组与第 1组间疗效存在显著性差异 (P <0 0 5 )。不良反应主要有恶心、呕吐、头痛、心悸及一过性低血压 ,第 2组的不良反应较多。结论应用氢化麦角碱及丹参治疗急性缺血性脑血管病 ,均有一定疗效 ,大剂量氢化麦角碱疗效更好 ,但是剂量加大 ,不良反应相应增多。ObjectiveTo observe the efficacy and safety of dihydroergotoxine in the treatment of acute ischemic stroke. Methods30 patients with acute ischemic stroke were randomly given dihydroergotoxine 0.6 mg(group 1), 1.5 mg (group 2) or Danshen injection 40 ml (group 3) respectively each day for 14 days,each for 10 cases. ResultsBefore and after treatment, the Scandinavian stroke scores of the three groups were increased( P <0.05). There was no significant difference( P >0.05) between the scores of group 1 and the group 3, but the scores of group 2 was higher than that of the group 3 and group 1( P <0.05). The common side-effect of both dihydroergotoxine groups were nausea, vomit, headache, palpitation and transient hypotention, which was more frequently apeared in group of 1.5 mg. ConclusionDihydroergotoxine and Danshen injection are all useful in the treatment of acute ischemic stroke. It is more efficient using higher dose of dihydroergotoxine. But as the dose going on, there will be more side-effect.

关 键 词：氢化麦角碱 脑卒中 丹参 

分 类 号：R743.3[医药卫生—神经病学与精神病学]