Multiple Functions of Nuclear DNA Helicase Ⅱ (RNA Helicase A) in Nucleic Acid Metabolism  

作　　者：SuishengZHANG FrankGROSSE 

机构地区：[1]DepartmentofBiochemistry,InstituteofMolecularBiotechnology,Beutenbergstrasse11,D-07745Jena,Germany [2]DepartmentofBiochemistry,InstituteofMolecularBiotechnology,POB100813,D-07708Jena,Germany

出　　处：《Acta Biochimica et Biophysica Sinica》2004年第3期177-183,共7页生物化学与生物物理学报（英文版）

摘　　要：Nuclear DNA helicase II (NDH II),or RNA helicase A (RHA),was initiallydiscovered in mammals by conventional protein purification methods.Molecular cloning identifiedapparent sequence ho-mologies between NDH II and a Drosophila protein named maleless (MLE),thelatter being essential for the Drosophila X-chromosome dosage compensation.Increasing amounts ofevidence suggest that NDH II is involved in multiple aspects of cellular and viral DNA and RNAmetabolism.Moreover the functions of NDH II may have potential clinical implications related toviral infection,autoimmune diseases,or even tumorigenesis.Nuclear DNA helicase II (NDH II),or RNA helicase A (RHA),was initiallydiscovered in mammals by conventional protein purification methods.Molecular cloning identifiedapparent sequence ho-mologies between NDH II and a Drosophila protein named maleless (MLE),thelatter being essential for the Drosophila X-chromosome dosage compensation.Increasing amounts ofevidence suggest that NDH II is involved in multiple aspects of cellular and viral DNA and RNAmetabolism.Moreover the functions of NDH II may have potential clinical implications related toviral infection,autoimmune diseases,or even tumorigenesis.

关 键 词：DNA and RNA helicase maleless (MLE) X-chromosome dosage compensation DSRBD RGG-box transcription RNA processing RNA transport actin NUCLEOLUS SLE (systemic lupuserythematosus) virus 

分 类 号：Q591.3[生物学—生物化学] Q55