丹参治疗小儿病毒性心肌炎的研究  

A Study of Salvia Miltiorrhizae in Treatment of the Viral Myocarditis

作　　者：孟祥春[1] 候久长 姜岩[1] 苗春秀 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,哈尔滨150086 [2]哈尔滨市第四医院

出　　处：《中国中西医结合杂志》1992年第6期345-347,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：为研究丹参对小儿病毒性心肌炎的治疗作用,共观察60例患儿,随机分为维生素C加三磷酸腺苷(ATP)加辅酶A(C0A)组30例(Ⅰ组),丹参加维生素C加ATP加CoA组30例(Ⅱ组),另选择正常儿童30例为对照组。于治疗前和1个疗程后测定血浆过氧化脂质(LPO)、红细胞膜微粘度、心肌酶和心电图。结果表明:两组患儿治疗前血浆LPO和红细胞膜微粘度均较正常明显增高(P<0.01),1个疗程后则均较治疗前明显降低(P<0.01),但Ⅰ组仍高于正常(P<0.05),且心肌酶和心电图恢复也较Ⅱ组明显落后(P<0.01)。提示丹参对病毒性心肌炎有明显治疗作用。In Order to evaluate the effect of Salvia. miltiorrhizae (SM) oh the acute viral myocarditis (AVM),60 children with AVM were studied. The patients were divided in random into two groups, group 1treated with vit. C, ATP, CoA(n=30), group II with SM plus vit.C, ATP, CoA(n=30). The levels of plasma lipid peroxide (LPO), erythrocyte membrane microviscosity (EMMV), LDH, CPK, GOT and ECG in each patient were determined before and after one course of treatments respectively, The results revealed that before treatment the levels of plasma LPO and EMMV in both groups increased significantly compaired with those of normal controls (n=30, P<0.01) respectively. There was a close correlation between LPO and EMMV (r=0.6774,P<0.01)and a close correlation between LPO and LDH (r=0.5703,P<0.01). After one course, the levels of plasma LPO and EMMV in both groups decreased significantly (comparded with those before treatment, P<0.01,respectively). But the LPO level and EMMV in group I were much higher than those in normal controls yet (P<0.05,respectively ). And LDH, GOT and ECG in nearly half of the patients in group I did not recover after one course while most patients in group II recovered. The results suggested that free radical plays an important role in the pathogenesis of AVM. SM as a good antioxidant, could protect myocardium from repairing membrane damage and clearing away free radical. This provided a new approach to treatment of viral myocarditis.

关 键 词：心肌炎 丹参 儿童 

分 类 号：R735.422.1[医药卫生—肿瘤]