过渡型CK19阳性表达细胞的研究  

Transitional CK19 positive cells-a new possible marker of hepatic precancerous lesion

作　　者：陈煜[1] 段钟平[1] 王宝恩[2] 贾继东[2] 陈光勇[3] 李忆梅[2] 

机构地区：[1]首都医科大学北京佑安医院人工肝中心,100054 [2]首都医科大学附属北京友谊医院肝病中心 [3]首都医科大学附属北京友谊医院病理科

出　　处：《中华肝脏病杂志》2004年第1期38-39,共2页Chinese Journal of Hepatology

摘　　要：目的 探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变的关系。 方法用LSAB免疫组织化学染色方法观察慢性乙型肝炎患者肝组织CK19的表达,每3个月对患者检查B超和血清甲胎蛋白,随访至1年。 结果 肝组织出现印圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者,大多数出现血清甲胎蛋白的明显升高。随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节。结论 过渡型CK19阳性表达细胞有可能作为一种新的肝癌前病变的病理学标志。Objective To investigate the relationship between Transitional CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients. Methods We observed the expression of CK19 in liver tissue of chronic hepatitis B patients by LSAB immunohistochemical staining, and examined serum AFP and ultrasonography one time per 3 months for one year. Results We observed a population of CK19 positive cells-with size and structure between those of human oval cells and mature hepatocytes-that usually occurred along with oval-cell proliferation. It was suggested that these transitional cells may partly account for the elevation of serum AFP. One patient occurred hepatic carcinoma, another patient had low-echogenic nodules in liver parenchyma within the 1 year follow-up period. Conclusions Transitional CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion.

关 键 词：过渡型CK19阳性表达细胞 肝细胞 肝癌 肿瘤 病毒 病理组织学 

分 类 号：R735.7[医药卫生—肿瘤]