息肉状脉络膜血管病变的随访观察  

The follow-up of polypoidal choroidal vasculopathy in Chinese patients

作　　者：文峰[1] 吴德正[1] 李海涛[1] 

机构地区：[1]中山大学中山眼科中心,广州510060

出　　处：《中华眼底病杂志》2004年第1期8-11,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金资助项目 (30 2 71 669) ;广东省医学科研基金资助项目 (960 61 )

摘　　要：目的　观察息肉状脉络膜血管病变 (PCV)的病程变化及视力预后。　方法　对 15例临床确诊的 PCV患者的 2 0只患眼行矫正视力和眼底彩色照相随访观察 ,随访时间 2～ 6 4个月 ,平均随访时间19.1个月 ;其中 10例 14只眼采用荧光素眼底血管造影 (FFA)和吲哚青绿血管造影 (ICGA)作了眼底形态学的随访 ,随访时间 3～ 5 3个月 ,平均随访时间 2 1.0个月。　结果　 2 0只眼中随访视力为 0 .3及其以上者5只眼 ,占 2 5 .0 % ;视力为 0 .1～ 0 .2者 6只眼 ,占 30 .0 % ;视力为 0 .1以下者 9只眼 ,占 4 5 .0 %。随访过程中 2只眼视力增进 ,占 10 .0 % ;10只眼视力稳定 ,占 5 0 .0 % ;8只眼视力下降 ,占 4 0 .0 %。仅 1只眼形成盘状瘢痕 ,占 5 .0 %。 14只眼底血管造影随访的患眼中 ,造影显示息肉状病灶稳定不变者 4只眼 ,占 2 8.6 % ;部分消退者 2只眼 ,占 14 .3% ;有扩展和新生者 6只眼 ,占 4 2 .8% ;消退和新生并存者 2只眼 ,占 14 .3%。　结论　 PCV患眼视力预后差异较大 ;在病程进展过程中息肉状病灶可增多、消退或稳定不变。Objective To observe the changes of disease course and the prognosis of visual acuity of Chinese patients with polypoidal choroidal vasculopathy (PCV). Methods Visual acuity and fundus photochromes of 20 eyes of 15 consecutive patients with PCV were followed up with a mean of 19.1 months (range from 2 to 64 months), in which the fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) of 14 eyes of 10 patients were followed up with a mean of 21.0 (range from 3 to 53) months. Results Among the 20 eyes, the visual acuity was more than 0.3 in 5 eyes (25.0%), between 0.1 and 0.2 in 6 (30 0%) and less than 0.1 in 9 (45.0%). During the follow-up, the visual acuity was improved in 2 (10.0%), stable in 10 (50.0%) and regressed in 8 (40.0%). Only 1 eye (5.0%) developed to macula scar. The result of ICGA revealed the polypoidal lesions that were unchanged in 4 eyes(28.6%), regressed in 2 (14.3%), grew in 6 (42.7%), repeatedly grew and spontaneously regressed in 6 (42.7%). Conclusions There is a large variation in the visual prognosis in Chinese patients with PCV. The polypoidal lesions can repeatedly grow and spontaneously regress in the natural course.

关 键 词：息肉状脉络膜血管病变 PCV 视力 吲哚花青绿 色素上皮 血管疾病 

分 类 号：R773.4[医药卫生—眼科]