猪肝小肠联合移植模型的建立  

Establishment of porcine combined liver/small bowel transplantation model

作　　者：尹震宇 李宁[1] 黎介寿[1] 李幼生[1] 倪小冬[1] 蒋峰[1] 

机构地区：[1]南京大学医学院临床学院普通外科研究所

出　　处：《中华器官移植杂志》2004年第2期86-88,共3页Chinese Journal of Organ Transplantation

摘　　要：目的　建立猪同种异体带胰头和十二指肠的肝小肠联合移植动物模型 (LSBT)。方法　动物为杂交长白猪 ,供器官包括少部分胰头、十二指肠、肝脏以及近端空肠 2～ 3m ,整块移植物移植到去除肝脏和全部小肠的受者猪。结果　在没有应用免疫抑制剂的情况下 ,猪移植术后中位生存时间为 92h ,最长时间为 196h ,其中有 75%的动物术后生存时间超过 2 4h。结论　猪的带部分胰头和十二指肠的肝小肠联合移植模型的成功建立 。ObjectiveTo set up the porcine combined liver/small bowel orthotopic allotransplantation model.MethodThe donors including liver, about 2 to 3?m proximal jejunum, duodenum and a sma ll part of pancreas head were transplanted to the hybridized long-white recipie nt pigs after the resection of their livers and the majority of small bowels.ResultWithout using immunosuppressive drugs, the median survival time of the animals w as 92?h with the longest survival time being 196?h, and there was about 75?% of the animals lived for more than 24?h after operation.ConclusionThe successful establishment of the combined liver/small bowel transplantation m odel will do great favor to our future clinical practice and further study of th e combined liver/small bowel transplantation.

关 键 词：肝移植 小肠移植 联合手术 动物模型 短肠综合征 肠外营养支持 肝功能衰竭 

分 类 号：R-332[医药卫生]