AFP阳性胃癌  

Serum AFP Contents in Patients with Gastric Cancer

作　　者：陈环球[1] 曾志毅[1] 沙允文[1] 张仁希[1] 

机构地区：[1]江苏省肿瘤防治研究所普瘤外科

出　　处：《中国肿瘤临床》1992年第1期33-35,共3页Chinese Journal of Clinical Oncology

摘　　要：作者检测了148例胃癌患者的血清标本,发现AFP阳性(AFP>20ng/ml)8例(5.4％)。其中AFP>400ng/ml者5例。平均年龄57岁,瘤体在胃窦部占6例,平均直径7.6cm,呈Borr-mannⅡ、Ⅲ型7例。Ⅳ期5例。肝转移5例(62.5％)。死亡5例平均生存期不到10个月。组织学检查中-高分化管状腺癌占7例。说明AFP阳性胃癌具有年龄偏大,胃窦部BorrmannⅡ、Ⅲ型为主,瘤体大,病期晚,组织学分化程度高的腺癌多见。肝转移率高,预后差为其特点。AFP检测、动态观察在胃癌诊治中有其重要意义。In 8(5.4％)of 148 cases of gastric carcinoma it was shown to have serum positive alpha-fetoprotein (AFP>20ng/ml).The serum AFP lvel in 5 of the 8 cases was greater than 400ng/ml.The average age of the patients of this series was 57 years. Grossly, tumor was located in the antrum in 6 cases and the average diameter of the tumor was 7.6cm. Seven of the 8 were of Borrmann's II, III types. Four had stage IV disease. Five had hepatic metastasis.The average survival time of the 5 who died was less than 10 months. Histologically, 7 were of highly to moderately differentiated tubular adenocarcinoma.It is shown that most of the gastric cancers with positive AFP were found in elder patients of Borrmann's II,III types in the an- trum with bulky mass, advanced stage and well differentiated adenocarcinoma.They are prone to have higher liver metastatic rate and poor prognosis.The authors con- sider that AFP assay and monitoring might be of important significance in the diag- nosis and follow-up of patients with gastric cancer.

关 键 词：胃肿瘤 癌 甲胎蛋白 

分 类 号：R735.2[医药卫生—肿瘤]