人 T 细胞白血病裸鼠异种移植瘤生长过程的病理形态学的动态观察  

Dynamic Patho-morphological Observation During Growth Process of Human T Cell Leukemia Transplanted in Nude Mice

作　　者：应红光[1] 褚建新[1] 胡小莉[1] 王文杰[1] 

机构地区：[1]中国医学科学院血液学研究所

出　　处：《中国肿瘤临床》1992年第2期154-156,共3页Chinese Journal of Clinical Oncology

摘　　要：本文采用裸鼠皮下多点移植的方法,动态地观察了人T细胞白血病裸鼠异种移植瘤在体内的生长过程,发现在潜伏期内移植的瘤块大部分坏死,由残留周边部的瘤细胞开始增殖。在瘤细胞增生旺盛期,少数瘤细胞出现凋落和瘤细胞吞噬凋落体现象。晚期瘤块中心出现坏死。这些观察为正确地判定抗癌药物的疗效有重要意义。In multiple site subcutaneous implantation the authors dynamically studied the patho-morphological changes during the growth process when human T lymphoblastoid leukemia cells were implanted in nude mice.It was found that in the latent phase the mass of tumor cells transplanted underwent necrosis,only those tumor cells at the periphery began to proliferate.In the proliferative phase a few of apoptotic cells could be found and some of them were phagocytized by other tumor cells.In the final phase the central part of the xenograft always showed necrosis.These findings are important for oorrect interpretation of the effect of anti-tumor drugs.

关 键 词：裸小鼠 生长特点 白血病 肿瘤移植 

分 类 号：R73－35[医药卫生—肿瘤]