凋亡抑制基因survivin在非小细胞肺癌中的表达  

A Novel Antiapoptosis Gene,Survivin Expression in Non-small-cell Lung Cancer

作　　者：丛德刚[1] 兰心刚[1] 胡永校[1] 赵惠儒[1] 张林[1] 

机构地区：[1]中国医科大学第一附属医院胸外科,沈阳市110001

出　　处：《中国肿瘤临床》2003年第6期428-430,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨survivin基因在非小细胞肺癌(NSCLC)中的表达。方法:应用免疫组织化学链霉菌抗生物素蛋白—过氧化酶连接(SP)法,检测survivin基因在76例NSCLC肿瘤组织、30例病灶旁正常肺组织中的表达。结果:survivin基因在正常肺组织不表达,76例肺癌组织中,46例表达阳性,占60.5%。survivin基因表达与肺癌患者的年龄、性别、吸烟、病理类型、分化程度、肿瘤大小、淋巴结转移及TNM分期无明显相关关系。结论:survivin基因在肺癌组织中的异常表达,对NSCLC发生发展起重要作用。survivin基因可能成为NSCLC新的诊断标志及基因治疗的新靶点。Objective:To study the expression of a novel inhibitor gene of ap op tosis,sur-vivin,in non-small-cell lung cancer.Methods:Using strepta-vid in-biotin peroxidase(SP)method,we examined the expression of survivin gene in30adjacent normal lung tissue samples and76NCSLC tu mor samples.Results :Survivin was expressed in46of76(60.5%)cases of lung cancer but was not expressed in30cases of adjacent normal lung tis sues.There was no relat ion ship be-tween survivin gene expression and age,sex,cigarette smoking,his tologic subtype,differen tiation,tumor size,lymph node metastases,or TNM sta ges.Conclusions:The survivin gene was ex pressed in a vast majority of NSCLC. Survivin gene may play a role in the pathway of carcinogenesis and be identified as a defining diagnostic marker and a potential therapeutic target in NSCLC.

关 键 词：基因SURVIVIN 肺癌 凋亡 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤] Q786[医药卫生—临床医学]