氯屈膦酸二钠治疗恶性肿瘤骨转移引起疼痛的疗效观察  

Treatment of Metastatic Bone Pain with Clodronate

作　　者：余萍[1] 黄波[1] 陈萍[1] 周行[1] 马红[1] 郝荣[1] 

机构地区：[1]四川省肿瘤医院,四川成都610041

出　　处：《肿瘤防治杂志》2003年第6期652-653,共2页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :观察国产氯屈膦酸二钠 (洛屈 )治疗恶性肿瘤骨转移引起疼痛的临床效果。方法 :共收治有溶骨性骨转移病灶的患者 4 6例 ,采用氯屈膦酸二钠 30 0mg/d ,静脉滴入 ,连用 5d ,3周为 1个疗程。结果 :止痛显效 18例 (39 1% ) ,有效 19例 (4 1 3% ) ,总有效率 80 4 % ,无效 9例。获效时间 5～ 30d ,有效病例 71 6 %在 2周内获效。 4 6例患者在用药过程中未见有严重不良反应 ,耐受性良好。结论 :国产氯屈膦酸二钠是一种治疗恶性肿瘤骨转移引起疼痛的有效药物 ,临床使用方便 。Objective To evaluate the efficacy of clodronate to relieve pain due to melastatic bone tumor.Methods Forty six patients were treated with clodronate 300 mg/d for 5 days.It was dissolved in 0 9% NS 500 mL and given by infusion for 4 hours.The treatment was repeated at 3 week intervals.Results Complete relief of pain was observed in 18 patients,partial relief in 19 patients.The rate of pain relief was 80 4%.The treatment was of no effect in 9 patients.Conclusions Clodronate is an effective drug in the treatment of cancer pain related with bone metastasis.

关 键 词：骨肿瘤 继发性 骨肿瘤 药物疗法 氯屈膦酸二钠 治疗应用 镇痛 

分 类 号：R738.1[医药卫生—肿瘤]