扇形PAMAM树枝状高分子的合成与表征  

SYNTHESIS AND CHARACTERIZATION OF FAN-SHAPE PAMAM DENDRONS

作　　者：王冰冰[1] 罗宇飞[1] 贾欣茹[1] 龚泳梅[1] 吉岩[1] 杨岭[1] 危岩 

机构地区：[1]北京大学化学学院,北京100871 [2]美国Drexel大学化学系,费城pa19104

出　　处：《高分子学报》2004年第2期304-308,共5页Acta Polymerica Sinica

摘　　要：An azyl group of ethylene diamine was protected by N-tert-butoxycarbonyl.The remaining azyl group then successively reacted with methyl acrylate, ethylene diamine and methyl acrylate again to afford the compound Boc-NH 2-(B-COOCH 3) 4 3 (AB-4).The ester groups and the Boc-end group of 3 were transferred to carboxylate 4 and azyl group 5 via hydrolyzation and deprotection respectively.The fan-shape dendron molecules with 16 exterior groups 6 were obtained by condensation of 4 and 5 in the presence of DCC.The dumbbell-like dendrimer molecules 7 could expediently prepared by coupling the dendrons with two functional groups of hexanedioyl chloride.The paper describes the synthesis procedures,reports the characterization results of FTIR、 1H-NMR、 13C-NMR and MALDI-TOF.Comparing with the PAMAM dendrimers from the divergent method, the synthesized compounds possess accurate structures and few defections.An azyl group of ethylene diamine was protected by N-tert-butoxycarbonyl. The remaining azyl group then successively reacted with methyl acrylate, ethylene diamine and methyl acrylate again to afford the compound Boc-NH2-(B-COOCH3)(4) 3 (AB(4)). The ester groups and the Boc-end-group of 3 were transferred to carboxylate 4 and azyl group 5 via hydrolyzation and deprotection respectively. The fan-shape dendron molecules with 16 exterior groups 6 were obtained by condensation of 4 and 5 in the presence of DCC. The dumbbell-like dendrimer molecules 7 could expediently prepared by coupling the dendrons with two functional groups of hexanedioyl chloride. The paper describes the synthesis procedures, reports the characterization results of FTIR, H-1-NMR, C-13-NMR and MALDI-TOF. Comparing with the PAMAM dendrimers from the divergent method, the synthesized compounds possess accurate structures and few defections.

关 键 词：PAMAM 扇形树枝状高分子 合成 表征 端基保护 脱保护 缩合 分子模拟 

分 类 号：O631[理学—高分子化学]