E-选择素对脑缺血再灌注中血氧分压的影响探讨  

Exploration of PO_2 after Cerebral Ischemia with Artificial Synthetic E-selectin

作　　者：李剑伟[1] 张世明[1] 谢学顺[1] 

机构地区：[1]苏州大学附属第一医院神经外科,苏州215006

出　　处：《中国血液流变学杂志》2004年第1期30-31,共2页Chinese Journal of Hemorheology

基　　金：江苏省回国人员资金项目 (NO 苏人通 [1998] 5号 )

摘　　要：目的　探讨有效治疗急性期脑缺血再灌注损伤的新药物。方法　采用线栓法制备大鼠大脑中动脉再灌注模型 ,建立模型后立即从股静脉注射E 选择素 ,然后连续测定PO2 3h。结果　治疗组比对照组PO2 明显升高。结论　E 选择素抗体对脑缺血再灌注损伤组织有提高PO2 ,从而达到保护脑组织的作用。Objective To explore a new drug to treat the injury of cerebral ischemia and reperfusion.Methods We made the local cerebral ischemic reperfusion model with thread embolism of left middle cerebral artery (MCA) in male SD rats. An artificial synthetic E-selectin was dissolved in physiological saline and injected intravenuously in the model of SD rats.Then PO 2 is moritored continuously for two hours. Results E-selectin can effectively increase PO 2 in brains after male SD rats ischemia and reperfusion.Conclusion An artificial synthetic E-selectin can effectively increase PO 2 in brain after cerebral ischemia so as to treat local reperfusion injury.

关 键 词：E-选择素 脑缺血再灌注 血氧分压 动脉闭塞模型 

分 类 号：R743[医药卫生—神经病学与精神病学]