精神分裂症的焦虑抑郁症状与血液流变学改变的关系  

The Relationship between Hemorheological Changes and the Anxiety and Depression Symptoms in Schizophrenia

作　　者：高镇松[1] 李章[1] 秦才来[1] 李植荣[1] 陈政雄[1] 

机构地区：[1]广东省汕头市第四人民医院,汕头515021

出　　处：《中国血液流变学杂志》2004年第1期65-67,99,共4页Chinese Journal of Hemorheology

摘　　要：目的　了解精神分裂症的焦虑抑郁症状与血液流变学改变的关系。方法　对符合CCMD 3的精神分裂症患者 14 8例分别于治疗前和 4周后进行血液流变学检测和比较 ,同时评定简明精神病量表 (BPRS)、汉密顿抑郁量表 (HAMD)和汉密顿焦虑量表 (HAMA) ,并与 6 0名健康者对照。结果　 1)入组时精神分裂症的焦虑抑郁症状 (HAMD、HAMA量表分 )与全血粘度(30 0s-1和 1s-1)、低切还原粘度和纤维蛋白原等指标都呈显著正相关 (P <0 .0 5～ 0 0 1)。 2 )伴焦虑抑郁组 77例 (HAMD总分 >17和 /或HAMA总分 >14分 )与 71例不伴发者比较 ,伴发组的全血粘度 (30 0s-1和 1s-1)、低切还原粘度和纤维蛋白原都显著高于对照 (非伴发组和健康组 ,P <0 .0 1) ,治疗后这种差异减轻甚至消失 (P <0 .0 5～ 0 0 1)。 3)伴焦虑抑郁组血液流变学 4W的变化值与焦虑抑郁的量表和因子的减分值也呈显著正相关 (P <0 .0 5～ 0 0 1)。结论　精神分裂症的焦虑抑郁症状与血液流变学改变的关系密切 ,伴焦虑抑郁症状的精神分裂症患者的高粘血症更突出 ,其高粘滞的程度与焦虑抑郁症状平行 ,联合抗抑郁药可有利于恢复。Objective To explore the relationship between the hemorheological changes and the anxiety and depression symptoms in schizophrenia.Methods 148 cases with schizophrenia of CCMD-3 were checked up for hemorheological indices and Brief Psychiatric Rating Scale (BPRS),Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale (HAMA) before and after 4 weeks of treatment.The data were compared among the groups and the control of the healthy.Results 1. In the group of schizophrenia,the anxiety and depression symptom(HAMD and HAMA) showed significantly positive correlation with the whole blood viscosity(300s -1 and 1s -1 ),low shear reduction viscosity and fibrinogen(P<0.05～0.01).2.The group of 77 cases with anxiety and depression symptom(HAMD>16 and /or HAMA>14) showed significantly higher than those of the control groups(without anxiety and depression,and the healthy,P<0.01).These differences showed significantly decreased or even disappeared after treatment(P<0.05～0.01).3.The 4 weeks variances of hemorheology in the group with anxiety and depression symptom showed significantly positive correlation with the reduced score of scales and factors of anxiety and depression (P<0.05～0.01).Conclusion There were close relationships between the hemorheological changes and the anxiety and depression symptom in schizophrenia.The schizophrenics with anxiety and depression symptom showed even obvious hypervis-semia.The levels of hypervis-semia were in parallel with the anxiety and depression symptoms. It's helpful in recovery to combine treatment with anti-depression drugs.

关 键 词：精神分裂症 焦虑抑郁 症状 血液流变学 高粘滞血症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]