吡拉西坦佐治帕金森病的临床疗效  被引量:2

Piracetam as an adjuvant in treatment of Parkinson's disease with used levodopa

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作  者:高翔[1] 郁青萍[1] 曹庆华[1] 

机构地区:[1]浙江宁波大学医学院附属医院神经内科,宁波315020

出  处:《中国临床药学杂志》2003年第3期141-143,共3页Chinese Journal of Clinical Pharmacy

摘  要:目的 :探讨吡拉西坦与多巴丝肼 (Ben Ldopa)联合治疗帕金森病 (PD)的疗效。方法 :3 7例PD患者在服用Ben Ldopa原剂量 1mo后 ,再在服用Ben Ldopa基础上增加吡拉西坦针剂 8~ 16g ,iv ,15~ 2 0d ;然后予吡拉西坦片剂 2g·d-1,po ,总疗程为 1mo。在应用吡拉西坦前后分别进行简易智力量表 (MMSE)评分、Webster功能评分 ,以及记录每日各例患者服用Ben Ldopa的剂量。结果 :吡拉西坦与Ben Ldopa联合应用后 ,MMSE评分均值提高≥ 4分的患者达 2 9例 ( 78 4% ) ,Webster评分均值减少≥ 3分者达 2 6例 ( 70 3 % ) ,Ben Ldopa剂量由联合治疗前的 ( 486± 2 2 3 )mg·d-1降至 ( 3 91± 2 2 3 )mg·d-1。结论 :吡拉西坦与Ben Ldopa联合应用于PD患者 ,可改善患者的认知功能 ,减轻运动障碍 ,降低BenAIM: To investigate the clinical value after adding piracetam when levodopa was used in treating Parkinson's disease (PD) on improving mini-mental state examination (MMSE) score, reducing PD movement disorders and reducing levodopa average amount daily. METHODS: Thirty-seven PD patients were given levodopa and MMSE score, Webster score and levodopa average amount used daily were recorded. Then they were recorded again when piracetam was added to 8-16 g·d -1, iv, for 15-20 d, and then 2 g·d -1 was prescribed orally for 10-15 d. RESULTS: After added piracetam, PD patient's 3 targets such as MMSE, Webster reduction and Levodopa average amount used in 37 cases all comparatively improved 9 cases (24.3%); 2 targets improved 22 cases (59.5%); 1 target improved 2 cases (5.4%); Invalid only was 4 cases (10.8%). The study was showed in 37 cases PD patients that about 78.4% (29 cases) increased in MMSE score, about 70.3% (26 cases) decreased in Webster score and about 48.6% (18 cases) reduced levodopa average amout daily when they were added piracetam than no it. CONCLUSION: It is obviously concluded that adding piracetam in PD patients can improve cognitive function, decrease movement disorders and reduce levodopa average amount daily.

关 键 词:吡拉西坦佐 帕金森病 临床疗效 辅助治疗 多巴丝肼 剂量 

分 类 号:R742.5[医药卫生—神经病学与精神病学]

 

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