离子型有机锡化合物的研究(Ⅱ)──在有机碱存在下三烃基氯化锡和三苯基氢氧化锡同巯基乙酸的反应  

Studies on Ionic Organotin Compounds(Ⅱ)──The Reaction of Trialkyltin Chloride and Triphenyltin Hydroxide withMercaptoacetic Acid in the Presence of Organic Bases

作　　者：孙丽娟[1] 宋雪清[1] 陈建新[1] 钟桂云[1] 谢庆兰[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《高等学校化学学报》2004年第4期646-650,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 3 72 0 3 5 )资助

摘　　要：以三烃基氯化锡和三苯基氢氧化锡在有机碱存在下同巯基乙酸反应 ,合成了 1 6个离子型有机锡化合物 .化合物的结构经元素分析、IR、 1H NMR、 13 C NMR和 119Sn确认和表征 .对其反应机理进行了探讨 ,测定了部分化合物对 Bel-740 2和 KB癌细胞的抑制活性 .The study of ionic tin compounds is current attention owing to their diversified molecular structure and wide range of application. Three kinds of ionic organotin compounds were obtained by the reaction of trialkyltin chloride and triphenyltin hydroxide with mercaptoacetic acid in the presence of organic bases. When Ph 3SnCl was treated with HSCH 2COOH, a novel complex [Ph 2ClSn (μ 2-SCH 2COO) ][R 3NH] was formed with the cleavage of Ph—Sn and the dephenylation mechanism was proposed and approved by Ph 3SnOH treated with HSCH 2COOH. All of the products were characterized by elemental analysis and 1H, 13 C, 119 Sn NMR. Antitumor activities of some compounds were tested for Bel-7402 and KB. The results show that the activities of compound B are better than compound A.

关 键 词：离子型有机锡化合物 有机碱 三烃基氯化锡 三苯基氢氧化锡 巯基乙酸 表征 反应机理 抗癌活性 

分 类 号：O627.42[理学—有机化学] R979.1[理学—化学]